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Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۱، صفحات ۳۸-۴۲
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عنوان انگلیسی Molecular epidemiology of colistin-resistant Pseudomonas aeruginosa producing NDM-1 from hospitalized patients in Iran
چکیده انگلیسی مقاله Objective(s): Resistance to carbapenems is the principal reason for the continuing utilization of colistin as a last resort choice for treating the infections resulted from multidrug carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates. The assessment of antimicrobial resistance pattern, the prevalence of carbapenem-resistance determinants, and molecular epidemiology of colistin-resistant isolates among CRPA strains were the aims of the present research. Materials and Methods: The current cross-sectional research was conducted on 269 CRPA isolates collected from various clinical samples from 2013 to 2016. After performing identification tests, disk diffusion as well as MIC methods were used for testing sensitivity to the antibiotics. Modified Hodge Test (MHT) was utilized to produce carbapenemase. PCR technique identified beta-lactamase classes A, B, and D genes. Results: In total, from 269 CRPA, five isolates (1.3%) were resistant to colistin. It was found that blaNDM-1, blaIMP-1, blaVIM-2, and blaOXA-10 genes were present in 40%, 40%, 20%, and 100% of colistin-resistant isolates, respectively. DLST type 25-11 is a significant cluster of colistin-resistant P. aeruginosa isolates. Conclusion: The appearance of colistin-resistant isolates in CRPA carrying blaNDM-1 with multiple carbapenem-resistant genes shows the great problem in the treatment of P. aeruginosa infections.
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نویسندگان مقاله | Ahmad Farajzadeh Sheikh
Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran|Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Mojtaba Shahin
Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran|Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Leili Shokoohizadeh
Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Mehrdad Halaji
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Fereshteh Shahcheraghi
Department of Bacteriology, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran


| Fahimeh Ghanbari
Student Research Committee, School of Medicine, Shahid Saddoughi University of Medical Sciences, Yazd, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_11761.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-1072898.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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