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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۶، صفحات ۴۸۴-۴۹۲
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Chemopreventive and biological activities of Helicteres isora L. fruit extracts
چکیده انگلیسی مقاله Helicteres isora L. ( H. isora ) has been used in traditional medicine in Asia. This study was aimed to determine biological activities of H. isora fruit extracts. Chemopreventive effect was examined by cell proliferation assay and differentiation-inducing effect. Anti-inflammatory activity of extracts was studied on the levels of nitric oxide (NO), tumor necrosis factor alpha (TNF-α), production of prostaglandin E2 (PGE-2), and cyclooxygenas-2 (COX-2). Cell proliferation assay revealed that H. isora extracts and its major compound, rosmarinic acid, showed no cytotoxicity in THP-1 and RCM-1 cells. Methylthio acetic acid from Cucumis melo var.conomon used as a positive control and 80% ethanol extracts demonstrated significant cell differentiation induction. Hexane extract of H. isora could lower the levels of TNF-α, PGE-2, and NO in THP-1 cells with 51.61 ± 0.79%, 69.68 ± 0.017%, and 69.93 ± 9.41% inhibition, respectively. The highest inhibitory effect on COX-2 was obtained from dichloromethane extract. Dexamethasone inhibited the secretion of TNF-α with 95.82 ± 0.50% while celecoxib showed the inhibitory effect on COX-2 and PGE-2 with 100% and 99.86%, respectively. The ethanol extract showed the best antioxidant activity by DPPH and FRAP assays at IC 50 of 5.43 ± 1.01 µg/mL and 22.83 ± 0.13 mmol FeSO 4 /g sample, respectively, while the positive control, trolox, showed the antioxidant activity with IC 50 and FRAP values at 4.08 ± 0.85 µg/mL and 10.84 ± 0.04 mmol FeSO 4 /g sample, respectively. Taken together, H. isora possess chemopreventive and antioxidant activity. Further studies on in vivo activities of this plant are suggested.
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نویسندگان مقاله | Acharaporn Rattanamaneerusmee
1Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand


| Krit Thirapanmethee
2Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Shimogamo-Hangi, Sakyo, Kyoto 606-8522, Japan. 3Horticultural Division, Kyoto Prefectural Agriculture, Forestry and Fisheries Technology Center, Amarube, Kameoka, Kyoto 621-0806, Japan.


| Yasushi Nakamura
4Department of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.


| Bhanubong Bongcheewin
1Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand


| Mullika Traidej Chomnawang


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1861
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1075795.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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