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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۶، صفحات ۵۲۳-۵۳۲
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عنوان انگلیسی The potential effects of hemp seed/evening primrose oils on the mammalian target of rapamycin complex 1 and interferon-gamma genes expression in experimental autoimmune encephalomyelitis
چکیده انگلیسی مقاله The mammalian target of rapamycin (mTOR) has a fundamental role in the metabolism, growth, and regulation of the immune system. The interferon gamma (IFN-γ)derived from T helper 1 (Th1) cells is a prominent pro-inflammatory cytokine in multiple sclerosis (MS) and its animal model, the experimental autoimmune encephalomyelitis (EAE). Due to the exclusive role of rapamycin (RAPA) in mTOR complex 1 (mTORC1) inhibition, essentially Th1 differentiation and IFN-γ production, we evaluated the potential therapeutic effects of hemp seed/evening primrose oils (HSO/EPO) in comparison with RAPA administration in EAE. To evaluate the therapeutic effects of EPO/HSO supplement in comparison with RAPA, EAE was induced using myelin oligodendrocyte glycoprotein (MOG) peptide and complete Freund's adjuvant in C57BL/6 mice. The weight, clinical score, and histological findings were evaluated. Total mRNA was extracted from local lymph nodes and qRT-PCR was used for the purpose of the genes expression level of regulatory associated protein of TORC1 ( RAPTOR ) and IFN-γ. Our results indicated that the relative expression of RAPTOR and IFN-γ genes were significantly reduced in HSO/EPO, RAPA, and RAPA + HSO/EPO treated groups in comparison with the untreated group. Interestingly, histological findings have shown that the HSO/EPO treated group remarkably regenerated the myelin sheath, but this did not occur in the case of RAPA or combined RAPA and HSO/EPO treated groups. Our findings suggeste that HSO/HPO can be used as a potent immunomodulator and as a good candidate for re-myelination and downregulation of immune response for treatment of MS.
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نویسندگان مقاله | Soheila Rezapour-Firouzi
1Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, I.R. Iran.


| Shahram Shahabi
2Departement of Immunology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, I.R. Iran.


| Adel Mohammadzadeh
3Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, I.R. Iran.


| Ali Asgar Tehrani
4Department of Biochemistry, School of Medicine, Urmia University of Medical Science, Urmia, I.R. Iran.


| Fatemeh Kheradmand
1Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, I.R. Iran.


| Ebrahim Mazloomi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1865
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1075799.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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