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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۶، صفحات ۵۳۳-۵۴۵
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عنوان انگلیسی Anti-melanogenesis and anti-tyrosinase properties of Pistacia atlantica subsp. mutica extracts on B16F10 murine melanoma cells
چکیده انگلیسی مقاله Pistacia atlantica (P. atlantica) subsp. mutica has been used in traditional medicine and is famous for its medicinal properties. The aim of this study was to evaluate the effect of methanol (MeOH), n -hexane, dichloromethane (CH 2 Cl 2 ), n -butanol (BuOH), ethyl acetate (EtOAc), water extracts and essential oil of P. atlantica subsp. mutica on melanin synthesis and oxidative stress in B16F10 melanoma cell line. The B16F10 cells viability after treatment with increasing concentrations of different extracts of the plant (0.2-200 µg/mL) was measured using resazurin. Essential oil composition was identified by gas-chromatography-mass spectrometry (GC-MS) analysis and inhibitory effect on synthesis of melanin, mushroom tyrosinase activity, cellular tyrosinase, and oxidative stress were evaluated by the colorimetric and fluorometric methods. The data showed extracts at concentrations 0.2-200 µg/mL, did not show significant toxicity on melanoma cells but concentrations of 200 µg/mL of essential oil had cytotoxic effect . Pistacia atlantica subsp. mutica could inhibit the mushroom tyrosinase activity. Also the amount of melanin in B16F10 cells declined. In addition, the ability of P. atlantica subsp. mutica extracts in decreasing the amount of reactive oxygen species in melanoma cells revealed remarkable antioxidant activity. In addition, all concentrations of essential oil had no significant effect in this study. The melanogenesis inhibitory and antioxidant effects of P. atlantica subsp. mutica on B16F10 cells may suggest the potential whitening activity of the plant for using in dermatological skin care products and for prevention of skin aging in cosmetic industry.
کلیدواژه‌های انگلیسی مقاله Anti-tyrosinase,Melanogenesis,P. atlantica subsp. mutica.
نویسندگان مقاله | Samira Eghbali-Feriz
2Department of Chemistry, Faculty of Science, Gonbad Kavous University, Gonbad Kavous, I.R. Iran.


| Akram Taleghani
3Department of Pharmacy, College of Health Science, Public Authority for Applied Education and Training (PAAET), Kuwait.


| Hadi Al-Najjar
1Department of Pharmacognosy, School of pharmacy, Mashhad university of Medical Sciences, Mashhad, I.R. Iran.


| Seyed Ahmad Emami
4Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.


| Homa Rahimi
1Department of Pharmacognosy, School of pharmacy, Mashhad university of Medical Sciences, Mashhad, I.R. Iran.


| Javad Asili
1Department of Pharmacognosy, School of pharmacy, Mashhad university of Medical Sciences, Mashhad, I.R. Iran.


| Samira Hasanzadeh


| Zahra Tayarani-Najaran


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1866
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-1075800.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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