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Journal of Dentomaxillofacil Radiology, Pathology and Surgery، جلد ۴، شماره ۱، صفحات ۲۵-۳۰
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عنوان انگلیسی Immunohistochemical analysis of Ki-67 expression in oral lichen planus lesions
چکیده انگلیسی مقاله Introdouction: Lichen planus is a chronic, relatively common, dermal mucosa disease. The World Health Organization (WHO) has introduced lichen planus as a premalignant condition. Ki-67 is a protein that can be detected in all active phases of the cell cycle, especially in the G2 and M phases. Considering the major role of Ki-67 in the regulation of the cell cycle and the fact that it is one of the conditions for pre-malignant potential and epithelial proliferation, the aim of this study was to evaluate Ki-67 expression in oral lichen planus (OLP) lesions. Materials and methods: This study included 32 patients [16 with OLP and 16 with no OLP and a normal epithelium, which were considered the control group (CG)]. Demographic data was extracted from each patient’s file and documented in an information form. Immunohistochemistry for Ki-67 was conducted using the EnVision method. P value was significant at < 0.05. Results: Ki-67 staining quality in the OLP group was significantly greater than the CG group according to both the Mann–Whitney test and quantity (p = 0.001). The average percentage of positive cells in the OLP group was 13.11, while the average in the CG group was 2.26. Ki-67 staining in OLPs was 87.5% (++) and 62% with a strong degree of staining. Age and gender differences were compared using the independent t-test no significant statistical differences were noted between the two groups. Conclusion: Considering Ki-67 is a proliferation marker, the increased expression of Ki-67 in the OLP group’s epithelium indicates a high proliferation rate in lichen planus lesions.
کلیدواژه‌های انگلیسی مقاله Lichen Planus, Oral , Ki-67 Antigen, Cell Cycle
نویسندگان مقاله نازنین بشردوست | nazanin bashardoust
department of oral and maxillofacial pathology, guilan university of medical sciences, rasht, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

شیرین مدبرنیا | shirin modabbernia
department of oral and maxillofacial pathology, guilan university of medical sciences, rasht, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

سارا باقری | sara bagheri
department of oral and maxillofacial pathology, guilan university of medical sciences, rasht, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

آتنا شیوا | atena shiva
department of oral and maxillofacial pathology, dental faculty, mazandaran university of medical sciences, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

رضا جلالی | reza jalali


نشانی اینترنتی http://3dj.gums.ac.ir/browse.php?a_code=A-10-1-71&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pathology
نوع مقاله منتشر شده پژوهشی
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