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Cell Journal، جلد ۱۸، شماره ۳، صفحات ۳۰۲-۳۰۹
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عنوان انگلیسی Mesenchymal Stromal Cells Implantation in Combination with Platelet Lysate Product Is Safe for Reconstruction of Human Long Bone Non::union::
چکیده انگلیسی مقاله Objective: Non::union:: is defined as a minimum of 9 months since injury without any visible progressive signs of healing for 3 months. Recent literature has shown that the application of mesenchymal stromal cells is safe, in vitro and in vivo, for treating long bone non::union::. The present study was performed to investigate the safety of mesenchymal stromal cell (MSC) implantation in combination with platelet lysate (PL) product for treating human long bone non::union::. Materials and methods: In this case series clinical trial, orthopedic surgeons visited eighteen patients with long bone non::union::, of whom 7 complied with the eligibility criteria. These patients received mesenchymal stromal cells (20 million cells implanted once into the non::union:: site using a fluoroscopic guide) in combination with PL product. For evaluation of the effects of this intervention all the patients were followed up by taking anterior-posterior and lateral X-rays of the affected limb before and 1, 3, 6, and 12 months after the implantation. All side effects (local or systemic, serious or non-serious, related or unrelated) were observed during this time period. Results: From a safety perspective the MSC implantation in combination with PL was very well tolerated during the 12 months of the trial. Four patients were healed; based on the control X- ray evidence, bony ::union:: had occurred. Conclusion: Results from the present study suggest that the implantation of bone marrow- derived MSCs in combination with PL is safe for the treatment of non::union::. A double blind, controlled clinical trial is required to assess the efficacy of this treatment (Registration Number: NCT01206179).
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نویسندگان مقاله | Narges Labibzadeh


| Mohsen Emadedin


| Roghayeh Fazeli


| Fatemeh Mohseni


| Seyedeh Esmat Hosseini


| Reza Moghadasali


| Soura Mardpour


| Vajiheh Azimian


| Maede Ghorbani Liastani


| Ali Mirazimi Bafghi


| Mohamadreza Baghaban Eslaminejad


| Nasser Aghdami


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4557
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