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Cell Journal، جلد ۱۶، شماره Suppl ۱، صفحات ۱۴۶-۱۴۶
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عنوان انگلیسی Ps-115: Increasing the Efficiency of Bone Chips in Non-::union:: Fracture Treatment Using Mesenchymal Stem Cells
چکیده انگلیسی مقاله Objective: Cell therapy has been used in treatment of so many different diseases, recently. Osteodisease is one of them which has been studied a lot and a bunch of researches has been allocated to it. Non-::union:: fracture is a subcategory of osteodisease and it usually appears in more than 20 percent of bone-feractures. The non-::union:: fracture financial load is the result of treatment expenses and disablement which is caused by the disease. Ignoring the treatment of this kind of disease, would lead to some clinical problems including inflammation and tumor which itself, is the indicator of importance of finding an appropriate treatment. Nowadays, methods for non-::union:: fracture treatment which has been used during operation are not so efficient. Materials and Methods: In this study, bone chips are strengthened with the help of adipose tissue-derived mesenchymal stem cells (ASCs) to increase the reparation ability of bone fracture. First, non-::union:: fracture is created in Rat, and then bone chip in combination with ASCs is applied to the place of bone fracture. The results have been considered by radiology, real-time PCR and histology. Results: Morphological fracture healing was evaluated by radiographical and histological examination 8 weeks after surgery. To evaluate the fracture healing process, relative callus areas around fracture sites in scanned radiographs at different time point were analyzed. The radiological and histological results showed the improvement in reparation of cells in non-::union:: fracture with the help of ASCs. To confirm the functional recovery of the fractured bone, biomechanical test was performed at week 8 in all groups. These findings indicated that incomplete ::union:: following bone fracture, repaired better in ASCs group than control group. Similarly, These results confirmed by real-time PCR. Conclusion: Therefore, ASCs in combination with bone chips would be a promising approach to speed up and repair of non-::union:: fracture.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/440
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