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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی P-46: Prevalence of Cancer Stem Cells in Breast Tumours and Its Corelation with Prognostic Factors, ER, PR and Erb2 to Find a New Therapeutic Target
چکیده انگلیسی مقاله Objective: Human breast tumors are heterogeneous and consist of phenotypically diverse cells. A subpopulation (CD44+/CD24-) of breast cancer cells has been reported to have stem/progenitor cell properties and invasive features. The importance of detection of breast cancer stem cells is due to its implication on development of new therapeutic strategies. The aim of this study was to investigate whether this subpopulation of cancer cells has any association with tumour characteristic and patient’s outcome or resistance to treatment. Materials and Methods: Double-staining immunohistochemistry was used to quantify CD44 and CD24 expression in 80 human breast tumors for which information on other tumour markers (ER, PR, p53, Her2) and clinical characteristics was available. Evaluation was performed by microscopic pathologic inspection and automated image analysis. Cells with red colour staining on the cell surface without much interfering from brown colour in cytoplasm were identified as CD44+/CD24_/low. Automatic image analysis was utilized to control for evaluation bias natural to subjective pathologic inspection for all cases. Results obtained by software analysis were then compared with those obtained by pathologic inspection. The final scoring was included in the database and compared to tumour characteristics, other tumour markers and patients’ survival. Results: At the time of diagnosis, the patients ranged in age from 28 to 65 years old (mean of 48 years). The most common histological type was Invasive Ductal Carcinoma (IDCA), comprising 83% of the cases. The majority of tumours were grade 2 (47%) or grade 3 (47%), and only 6% of cases were grade 1. The prevalence of CD44+/ CD24- cells in this series of tumours was < 10% in the majority (83%) of cases and > 10% in the reminder (17%). A complete lack of both proteins was evident in 34% of tumours, whereas 11% of tumours express both proteins in > 75% of their cells. The prevalence of CD44+/CD24- /low was significantly associated with tumour grade and prognosis, while it had no impact on other tumour characteristics. Conclusion: Our finding suggest that the prevalence of CD44+/CD24- /low tumour cells in breast cancer may not be associated with clinical outcome but may be associated with prognosis. Majority of anticancer therapies target non-tumourigenic cells in tumour, while cancer stem cells are still survive and leading to tumour recurrence. Therefore, strategies designed to target cancer stem cells in combination with current treatments may lead to more effective therapies.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1578
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