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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی O-21: Immunophenotyping of Acute Lymphoblastic Leukemia Children Referred to Amirkola Children's Hospital
چکیده انگلیسی مقاله Objective: Immunophenotyping is one of the contributing factors in determining the type and intensity of treatment in patients with acute lymphoblastic leukemia. The aim of this study was to determine the frequency distribution of acute lymphoblastic leukemia immunophenotyping by flow cytometry in patients referred to Amirkola Children's Hospital affiliated to Babol university of Medical Sciences. Materials and Methods: The study population was children with acute lymphoblastic leukemia under 14 years age admitted to Amirkola Children's Hospital. Bone marrow samples of 352 patients were sent to blood transfusion flow cytometry centre of Iran to determine CD markers and then according to maximum percentage of CD markers, leukemic cells groups and subgroups were determined and the relationship between prognostic factors with the type of leukemic cells was evaluated. Results: According to flow cytometry, 33 patients (9.2%) had T-cell immunophenotype, 26 ones (7.2%) had B-cell immunophenotype, 145 cases (40.4%) had Early pre B cell, 124 cases (34.5%) had Pre B cell and 24 ones (58.8%) had Pro B cell. The mean age of patients was 6±4 years and 47.1% of them were in the age group of 1-5years. 58.8% of patients were male and 41.2% were female. Conclusion: Results from the findings of this study shows similar characteristics of children with acute lymphoblastic leukemia with other areas of the world and more study on disease prognosis and its relationship with cell markers (immunophenotyping) in Northern Iran is essential.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1529
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