این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Nanomedicine Journal، جلد ۲، شماره ۳، صفحات ۲۱۱-۲۱۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of gold nanoparticles on postoperative peritoneal adhesions in rats
چکیده انگلیسی مقاله Objective(s): Abdominal adhesions are one of the most important problems, occurring after intra-abdominal surgery in more than 90% of cases. This condition is the leading cause of bowel obstruction, infertility, and abdominal/pelvic pain. Gold nanoparticles (GNPs) have been shown to be non-toxic and exhibit anti-inflammatory, anti-angiogenic and antioxidant activities. The purpose of this study was to determine the effect of intraperitoneal lavage with GNP solutions on the development of postoperative peritoneal adhesion (PPA). Materials and Methods:In the current experimental study, thirty-five male Wistar rats were randomly assigned to seven groups of five rats. After a standardized peritoneal injury, GNP solutions in different concentrations (1, 2.5, 5, 10, 50 and 100 ng/ml) were locally administered through nebulization; normal saline (NS) was administered to the control group. Two weeks later, the rats were sacrificed and cecum and peritoneal samples were harvested for histopathological assessment. Blood samples were obtained to determine serum concentrations of inflammatory biomarkers including tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β) and vascular endothelial growth factor (VEGF). Results: The rats treated with GNPs had significantly lower microscopic and macroscopic peritoneal adhesion scores, compared to the control group (P< 0.05). Score 5 of macroscopic adhesions was reported in all the rats of the control group, unlike the GNP groups. Furthermore, microscopic adhesions were reported with all rats in the control group, unlike the GNP groups (reported in 0 out of 5 rats in all GNP groups). In addition, serum levels of IL-1β, TNF-α and VEGF underwent no significant changes. Conclusion: Compared to the control group, GNPs decreased the severity of peritoneal adhesions, although they did not alter TNF-α, IL-1β or VEGF serum levels.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله امیرهوشنگ محمدپور | amir hooshang mohammadpour
department of clinical pharmacy, school of pharmacy, pharmaceutical research center, mashhad university of medical sciences, mashhad iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

علیرضا توسلی | alireza tavassoli
endoscopic minimally invasive surgery research centre, ghaem hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمدرضا خاکزاد | mohammad reza khakzad
allergy research center, mashhad university of medical sciences, mashhad, iran, department of immunology, mashhad branch, islamic azad university, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

الهه زیبایی | elahe zibaee
department of clinical pharmacy, school of pharmacy, mashhad university of medical science, mashhad, iran


محمد افشار | mohammad afshar
department of anatomy, faculty of medicine, birjand university of medical sciences, birjand, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بیرجند (Birjand university of medical sciences)

محمود هاشمزایی | mahmoud hashemzaei
department of pharmacology and toxicology, school of pharmacy, zabol university of medical science

سازمان اصلی تایید شده: دانشگاه زابل (Zabol university)

غلامرضا کریمی | gholamreza karimi
medical toxicology research center, school of pharmacy, mashhad university of medical science, mashhad iran
نشانی اینترنتی http://nmj.mums.ac.ir/article_4477.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده 1
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات