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Nanomedicine Journal، جلد ۱، شماره ۴، صفحات ۲۶۷-۲۷۵
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عنوان انگلیسی Green synthesis of silver nanoparticles: The reasons for and against Aspergillus parasiticus
چکیده انگلیسی مقاله Objective(s): The enzymatic activity of fungi has recently inspired the scientists with re-explore the fungi as potential biofactories rather than the causing agents of humans and plants infections. In very recent years, fungi are considered as worthy, applicable and available candidates for synthesis of smaller gold, silver and other nano-sized particles. Materials and Methods: A standard strain of Aspergillus parasiticus was grown on a liquid medium containing mineral salt. The cell-free filtrate of the culture was then obtained and subjected to synthesize SNPs while expose with 1mM of AgNO3. Further characterization of synthesized SNPs was performed afterward. In addition, antifungal activity of synthesized SNPs was evaluated against a standard strain of Candida albicans. The reduction of Ag+ ions to metal nanoparticles was investigated virtually by tracing the color of the solution which turned into reddish-brown after 72h. Results: The UV-vis spectra demonstrated a broad peak centering at 400nm which corresponds to the particle size much less than 70nm. The results of TEM demonstrated that the particles were formed fairly uniform, spherical, and small in size with almost 90% in 5-30nm range. The zeta potential of silver nanoparticles was negative and equal to -15.0 which meets the quality and suggested that there was not much aggression. Silver nanoparticles synthesized by A. parasiticus showed antifungal activity against yeast strain tested and exhibited MIC value of 4 μg/mL. Conclusion: The filamentous fungus, A. parasiticus has successfully demonstrated potential for extra cellular synthesis of fairly monodispersed, tiny silver nanoparticles.
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نویسندگان مقاله مریم موذنی | maryam moazeni
invasive fungi research centre, department of medical mycology amp; parasitology, school of medicine,mazandaran, university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

احمدرضا شاهوردی | ahmad reza shahverdi
department of pharmaceutical biotechnology, faculty of pharmacy and biotechnology research center, tehranuniversity of medical sciences, tehran, iran


مجتبی نبیلی | mojtaba nabili
invasive fungi research centre, department of medical mycology amp; parasitology, school of medicine,mazandaran, university of medical sciences, sari, iran, social security organization, golestan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

فاطمه نوربخش | fatemeh noorbakhsh
department of biology, islamic azad university, varamin-pishva branch, varamin, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

ساسان رضایی | sassan rezaie
department of medical biotechnology, school of advanced technologies in medicine, tehran university ofmedical sciences, tehran, iran| department of medical mycology amp; parasitology, school of public health, tehran university of medicalsciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://nmj.mums.ac.ir/article_2751.html
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