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Asia Pacific Journal of Medical Toxicology، جلد ۳، شماره ۳، صفحات ۱۰۴-۱۰۹
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عنوان انگلیسی Methadone Related Poisoning on the Rise in Tehran, Iran
چکیده انگلیسی مقاله Background: In Iran, methadone has been used for methadone maintenance treatment (MMT) as well as analgesic treatment in pain clinics. Recently, there are some reports regarding accidental and intentional methadone poisonings and deaths. The aim of this study was to evaluate the trend of methadone poisonings and deaths during a 10-year period in Tehran, Iran. Methods: This was a retrospective cross-sectional study over 2000 to 2010. Patients with a documented methadone poisoning who were admitted in Loghman Hakim Hospital Poison Center in Tehran, Iran were identified and included in the study. The data including patients' age, gender, ingested dose, co-ingestants, intention of ingestion and outcome were extracted from the patients' medical records. Results: During the study period, 1426 cases of methadone poisoning were recorded, of which, 1041 cases (73%) were men. Thirty-six cases (2.5%) died. Mean age of the patients was 29.9 ± 17 years. In 476 cases, the intention of poisoning could not be determined, and in the remaining, the intention was misuse (n = 273, 28.7%), suicide (n = 254, 26.7%), accidental (n = 245, 25.8%) and abuse (n = 178, 18.8%). Mean of the ingested dose of methadone was 120.6 ± 306.8 mg. The incidence of acute methadone poisoning per one million population of Tehran was 0.43 in 2000 that rose to 37.62 in 2010. Conclusion: The results indicate that methadone poisoning and deaths have increased in Tehran. MMT clinics should be strictly run according to the national guideline to prevent methadone poisoning. With regard to high frequency of poly-drug use in methadone poisoning, it seems important to warn health care providers against prescription of other drugs with methadone. 
کلیدواژه‌های انگلیسی مقاله Death, Incidence, Iran, Methadone, Poisoning
نویسندگان مقاله کامبیز سلطانی نژاد | kambiz soltaninejad
legal medicine research center, legal medicine organization of iran, tehran, iran


حسین حسنیان مقدم | hossein hassanian moghaddam
excellent center of clinical toxicology, toxicology research center, department of clinical toxicology, loghman hakim hospital, school of medicine, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

شاهین شادنیا | shahin shadnia
excellent center of clinical toxicology, toxicology research center, department of clinical toxicology, loghman hakim hospital, school of medicine, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://apjmt.mums.ac.ir/article_3378.html
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