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Journal of Cardio-Thoracic Medicine، جلد ۱، شماره ۲، صفحات ۴۷-۵۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparison of Two Different Induction Doses of Atracurium in Myasthenia Gravis in Patients Undergoing Thymectomy
چکیده انگلیسی مقاله Introduction:yasthenia gravis is an autoimmune disorder resulting from a decreased number of active acetylcholine receptors at the neuromuscular junction. Thymectomy is one of its current treatments. Due to sensitivity of myasthenic patients to non-depolarizing muscle relaxants and also the interaction of this medication with anti-cholinestrase drugs, determining the dosage of non-depolarizing muscle relaxants for induction of anesthesia is one of the hurdles in thymectomy. Materials and Methods :20 myasthenic patients undergoing transsternal thymectomy were enrolled into the study.They were divided into two groups randomly, and received either 0.25 mg/kg or 0.50 mg/kg of atracurium to facilitate tracheal intubation. Neuromuscular blockade was measured using train of four (TOF) mode of neuromuscular stimulator 15 minutes after administration of atracurium and then each 5 minutes till entered the recovery phase. The time between injection of atracurium and the recovery phase was compared between the two groups. Results:The two groups were similar with respect to age and gender. The time from the onset of myasthenia gravis to surgery, dosage and duration of pyridostegmine used preoperatively were not significantly different between the two groups.The time from administration of atracurium to recovery phase was not significant between the two groups (P=0.24). Conclusion:There was no difference between two different doses of atracurium regarding entering the recovery phase, and as the effects of non-depolarizing muscle relaxants are unpredictable in myasthenic patients, we recommend the lower dose to prevent profound skeletal muscle weakness and postoperative complications
کلیدواژه‌های انگلیسی مقاله Atracurium Myasthenia Gravis Pyridostegmine Thymectomy
نویسندگان مقاله علیرضا شریفیان عطار | alireza sharifian attar
anesthesiologist, cardio- thoracic surgery amp; transplant research center, emam reza hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

رضا جلاییان تقدمی | reza jalaeian taghaddomi
anesthesiologist, anesthesia department, ghaem hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حسین فتاحی معصوم | hossein fattahi masoum
thoracic surgeon, thoracic surgery department, ghaem hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محسن فروغی پور | mohsen foroughipour
neurologist, neurology department, ghaem hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمدرضا هدایتی مقدم | mohammad reza hedayati moghaddam
research center for hiv aids, htlv and viral hepatitis, iranian academic center for education, culture amp; research acecr , mashhad branch,mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

پریسا محبی | parisa mohebbi
resident of anesthesiology, ghaem hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://jctm.mums.ac.ir/article_909.html
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