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Acta Medica Iranica، جلد ۵۶، شماره ۹، صفحات ۵۵۹-۵۶۲
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عنوان انگلیسی Investigation of Serum Levels and Activity of Matrix Metalloproteinases 2 and 9 (MMP2, 9) in Opioid and Methamphetamine-Dependent Patients
چکیده انگلیسی مقاله Matrix metalloproteinases (MMPs) are a group of zinc-dependent proteolytic enzymes that play a role in extracellular matrix (mainly collagen) degradation and remodeling. MMPs are not only causes of the increase rewarding effects of drugs, but also act as pro-addictive agents. In this research, 22 morphine and 20 methamphetamine-dependent patients included and their serum levels and activity of MMP2 and 9 were assessed by ELISA and gelatin zymography and compared with those of 23 healthy individuals as a control group. Our findings showed a significant increase in serum levels and activity of MMP-2 in opium and methamphetamine groups in comparison with the control group. Moreover, unlike MMP-2, serum levels and activity of MMP-9 in both case groups found to be decreased. This study showed that long-term abuse of opium and methamphetamine changes the activity and serum levels of MMP9 and MMP2. The effects of methamphetamines and opium are associated with an increase in extracellular dopamine levels in the brain, achieved by facilitating the release of dopamine from pre-synaptic nerves. Our findings showed that serum levels and activities of MMP-9 and MMP-2 could be considered as alternative valuable biomarkers from those investigated of pro-addictive or anti-addictive factors in dependent patients.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Khadijeh Najafi
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AND Department of Immunology, Tabriz University of Medical Sciences, Tabriz, Iran.


| Daniel Elieh Ali Komi
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. AND Substance Abuse Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Habibolah Khazaie
Department of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Ali Moini
Department of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Asad Vaisi-Raygani
Substance Abuse Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Hamid Reza Ahmadi
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Mohammad Rasoul Ghadami
Department of Pharmacology and Toxicology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. AND Regenerative Medicine Research Center (RMRC), Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Amir Kiani


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7396
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-1141612.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Articles
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