این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Acta Medica Iranica، جلد ۵۶، شماره ۹، صفحات ۵۶۳-۵۷۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Luteolin Reduced the Traumatic Brain Injury-Induced Memory Impairments in Rats: Attenuating Oxidative Stress and Dark Neurons of Hippocampus
چکیده انگلیسی مقاله Traumatic Brain Injury (TBI) is generally recognized as a major risk factor for memory impairments and Alzheimer’s disease (AD). In this experimental study, our aim was to investigate the ameliorating effects of luteolin (LUT) on the memory impairments, oxidative stress, and histopathological changes induced by TBI in rats. The adult male Wistar rats were randomly divided into six groups including: Control (Co), sham, TBI, TBI+LUT (10 mg/kg), TBI +LUT (25 mg/kg), TBI +LUT (50 mg/kg). To evaluate the protective effects of LUT on the memory of the rats, passive avoidance test using shuttle box was performed. Finally, the animals were anesthetized, and the brain tissues were removed and analyzed for oxidative stress parameters. Using histological methods, dark neuron production was also evaluated. There was a significant decrease in the latency time to enter the dark compartment in passive avoidance test in TBI animals. This latency time was significantly increased in TBI+LUT (25 mg/kg) and TBI+LUT (50 mg/kg) groups along with significant increases in superoxide dismutase and catalase activity in the hippocampal zone and a decrease in malondialdehyde (MDA). The number of dark neurons in the hippocampus decreased with all three doses of LUT. In the present study, LUT showed neuroprotective effects, improvement in learning and reduction in memory impairment induced by TBI in rats. Protection against oxidative stress might be a possible mechanism behind these effects. Further works are necessary to work out if LUT is potentially a suitable therapeutic candidate for neural disorders.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Zeinab Ashaari
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Gholamreza Hassanzadeh
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran. AND Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.


| Tahmineh Mokhtari
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Mahmoud Hosseini
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.


| Zakieh Keshavarzi
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Mohsen Amini
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Kowsar Bavarsad
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Sahar Ijaz
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Mousa-Al-Reza Hadjzadeh


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7437
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-1141613.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات