این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Molecular Biology Research Communications، جلد ۷، شماره ۴، صفحات ۱۸۱-۱۸۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Screening of CYP1B1 Arg368His as predominant mutation in North Indian primary open angle glaucoma and juvenile onset glaucoma patients
چکیده انگلیسی مقاله In India, mutations in Cytochrome P450 (CYP1B1) are a predominant cause of not only primary congenital glaucoma (PCG) but also involved in primary open angle glaucoma (POAG) and juvenile onset glaucoma (JOAG). After ethical clearance, 100 POAG patients, 30 primary angle closure glaucoma (PACG) patients and 130 ethnically matched controls were recruited in this study. Genomic DNA was isolated from the blood and screened for p.Arg368His mutation in CYP1B1 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). On PCR-RFLP, 10/100 cases (10%) were found positive for Arg368His mutation. In North Indian POAG cases studied, p.Arg368His mutation was found only in heterozygous state. The frequency of p.Arg368His CYP1B1 mutation in heterozygote state (10.0%) observed in our study in North Indian POAG patients is the highest in comparison to frequency observed in other ethnic groups from Southern and Eastern India.Keywords: North Indian, POAG, p.Arg368His, CYP1B1
کلیدواژه‌های انگلیسی مقاله North Indian, POAG, p.Arg368His, CYP1B1
نویسندگان مقاله Avneet Kaur |
Department of Biotechnology, GGDSD College, Sector-32C, Chandigarh (UT) India-160030

Vanita Vanita |
Department of Human Genetics, Guru Nanak Dev University, Amritsar 143005, India

JaiRup Singh |
Department of Human Genetics, Guru Nanak Dev University, Amritsar 143005, India

نشانی اینترنتی http://mbrc.shirazu.ac.ir/article_5066_2998a0660e94e288d6e6105f02474a8a.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/526/article-526-1141920.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات