این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۲، شماره ۲، صفحات ۱۱۲-۱۱۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Depression was associated with apolipoprotein E ε4 allele polymorphism: A meta-analysis
چکیده انگلیسی مقاله Objective(s): Previous studies have reached different conclusions regarding an association between apolipoprotein E (APOE) polymorphisms and depression. This meta-analysis was designed to clarify these controversies. Materials and Methods: Literatures were identified reviewing the national and international databases. The eligible articles for meta-analysis were determined by quality assessment and implementation of inclusion/exclusion criteria. This meta-analysis was performed using Review Manager 5.2 software. The odds ratios (ORs) with corresponding 95% confidence interval (CIs) were calculated using a fixed effects model. Funnel plots and Egger's regression tests were used to assess the publication bias. Results: A total of nine studies that met the inclusion criteria were identified by performing a comprehensive search on the association between APOE polymorphisms and depression. APOE ε4 allele was significantly associated with depression (allele: OR=1.36, 95%CI=1.11-1.66, P=0.003; dominant: OR=1.34, 95%CI=1.06-1.68, P=0.001; recessive: OR= 1.11, 95%CI =0.45-2.76, P=0.82). HAMD scores were higher in depression patients with-APOE ε4 genotype than who without-APOE ε4 genotype (OR=0.96, 95%CI=0.16-1.76, P=0.02). Conclusion: APOE ε4 allele increased the depression risk; depressive patients carrying APOE ε4 allele had more severe depressive symptoms.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Wei-wei Wang
The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China


| Xiao-lei Liu
The First Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China


| Ye Ruan
Mental Health Center of Kunming Medical University, Kunming City, Yunnan Province, PR China


| Lin Wang
The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China


| Tianhao Bao
The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China|Mental Health Center of Kunming Medical University, Kunming City, Yunnan Province, PR China
نشانی اینترنتی http://ijbms.mums.ac.ir/article_12084.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-1142606.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات