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Journal of Medical Bacteriology، جلد ۵، شماره ۳, ۴، صفحات ۲۹-۴۰

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عنوان انگلیسی Prevalence of Nontuberculous Mycobacteria (NTM) in Iranian Clinical Specimens: Systematic Review and Meta-Analysis
چکیده انگلیسی مقاله Background: Although, nontuberculous mycobacteria can cause disease in different organisms, they usually are not reported in most countries because scientists in general consider them as non-pathogens. But, increasing nontuberculous mycobacteria diseases occurrence has changed this belief. Nevertheless, there is no meta-analysis review about prevalence of nontuberculous mycobacteria in Iran. Methods: Any data about prevalence of nontuberculous mycobacteria in clinical specimens in Iran were retrieved by searching data bases such as Pub Med, MEDLINE, and Iranian data bases. Then the meta-analysis was performed by comprehensive meta-analysis software (CMA). Results: The meta-analysis showed that the prevalence of nontuberculous mycobacteria in the clinical specimens in Iran was 1.3%. In the studies that had sample size less than 300, and in studies conducted after 2004, the prevalence was higher. Also, the prevalence of nontuberculous mycobacteria was higher in the West of Iran. In this study, the most prevalent rapid-growing mycobacterium was Mycobacterium. fortuitum and most prevalent slow-growing mycobacterium was M. simiae with the prevalence 44.2% and 14.3%, respectively. Conclusion: M. simiae is the most prevalent nontuberculous mycobacteria in the clinical specimens in Iran. As this species of nontuberculous mycobacteria has similar clinical and radiological manifestations with tuberculosis, it is often treated as tuberculosis. Unfortunately, M. simiae is resistant against first-line anti-TB drugs resulting in treatment failure after using routine anti-TB medication. Therefore, there is an urgent need for application of new diagnostic strategy for identification of nontuberculous mycobacteria species.
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نویسندگان مقاله آزاد خالدی | azad khaledi
1 antimicrobial resistance research center, avicenna research institute, department of microbiology and virology, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

عباس بهادر | abbas bahador
department of microbiology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

داود اسماعیلی | davoud esmaeili
applied microbiology research center, and microbiology department, baqiyatallah university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کیارش قزوینی | kiarash ghazvini
antimicrobial resistance research center, avicenna research institute, department of microbiology and virology, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)


نشانی اینترنتی http://jmb.tums.ac.ir/index.php/jmb/article/view/197
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