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Journal of Medical Bacteriology، جلد ۴، شماره ۳-۴، صفحات ۴۵-۵۵
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عنوان انگلیسی Encapsulation of Platelet in Kefiran Polymer and Detection of Bioavailability of Immobilized Platelet in Probiotic Kefiran as a New Drug for Surface Bleeding
چکیده انگلیسی مقاله Background : Kefir contains lactic acid bacteria ( Lactobacillus , Lactococcus , Leuconostoc , Acetobacter and Streptococcus ) and yeasts ( Kluyveromyces , Torula , Candida , and Saccharomyces ). Kefiran is the polysaccharide produced by lactic acid bacteria in kefir. Methods : Kefiran was prepared from milk containing 0.5% fat and 10 grams kefir grains and was separated from kefir by ethanol (0.02 gram) following entrapping the platelets to this polymer. Ligand of the platelet-polysaccharide was studied by FTIR. Results : FTIR results showed that the bands of C-O and C-O-C connections were formed and the polysaccharides had been attached to the receptors of the platelet glycoproteins (GP Ib, GPIIb / IIIa). Stability and encapsulation of the platelet and kefiran were assessed by Coulter Counter. Encapsulation of the platelets by polysaccharide at the beginning caused to reduce the number of platelets following by releasing of 50% of the platelets after 3 hours. Conclusion : The platelets were encapsulated in kefiran polymer and detected for bioavailability as new drug for surface bleeding. Also, kefiran has antimicrobial and antifungal properties. On the other hand, the existence of nisin in kefiran could be useful as an antibacterial lantibiotic.
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نویسندگان مقاله آناهیتا جناب | anahita jenab
department of biology, faculty of sciences, university of isfahan, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

رسول روغنیان | rasoul roghanian
department of biology, faculty of sciences, university of isfahan, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

گیتی امتیازی | giti emtiazi
department of biology, faculty of sciences, university of isfahan, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

نشانی اینترنتی http://jmb.tums.ac.ir/index.php/jmb/article/view/209
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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