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Journal of Medical Bacteriology، جلد ۴، شماره ۱-۲، صفحات ۲۷-۳۴
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عنوان انگلیسی Molecular Detection of Extended-Spectrum Beta-Lactamase in Isolated Bacteria from Blood Cultures
چکیده انگلیسی مقاله Introduction : ESBLs are a B -lactamases which had ability to hydrolyse third-generation cephalosporins and aztreonam. ESBLs producer bacteria are resistant to a wide variety of antimicrobials and they made a serious global health concern for treatment strategies. So, aim of this study as to molecular detection of ESBLs in bacteria isolated from blood cultures in hospitals from Kurdistan Province, Iran. Methods : Biochemical test, antimicrobial susceptibility test by disc method, ESBL detection by NCCLs Phenotypic and PCR method for ESBL detection were applied. Results were analyzed by using SPSS 11.5 (p < 0.05). Results : 96 S. epidermidis isolated from blood cultures, E. coli, Enterobacter spp., Klebsiella spp., P. aeruginosa, Salmonella spp., C. freundii, S. maltophilia, also S. aureus, and S.epidermis. Maximum resistance was 75% for CP and minimum resistance was 25% for GM. Of the 96 isolates, 20 (20.83%) produced ESBLs. Also 11.46%, 20.83%, 12.5%, 9.38% and 2.08% were positive for TEM, CTX-M, SHV, OXA-1 and OXA-2 ensymes, respectively. Conclusion : Inappropriate therapy for infections with ESBL producers is cause of prolongs hospital stay and mortality. So, more research on drug resistance with ESBL is necessary.
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نویسندگان مقاله رشید رمضان زاده | rashid ramazanzadeh
cellular amp;amp; molecular research center and microbiology department, faculty of medicine, kurdistan university of medical sciences, sanandaj, iran.


سمانه روحی | samaneh rouhi
cellular amp;amp; molecular research center and microbiology department, student research committee, kurdistan university of medical sciences, sanandaj, iran.


پگاه شکیب | pegah shakib
cellular amp;amp; molecular research center and microbiology department, student research committee, kurdistan university of medical sciences, sanandaj, iran.
نشانی اینترنتی http://jmb.tums.ac.ir/index.php/jmb/article/view/172
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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