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Journal of Medical Bacteriology، جلد ۲، شماره ۱-۲، صفحات ۳۵-۴۰
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عنوان انگلیسی The Sensitization of Legionella pneumophila to Some Antibiotics by Reserpine and Anti-Legionella Effects of Different Benzofuranone Derivatives
چکیده انگلیسی مقاله Ba ckground: Legionella pneumophila is a dangerous pathogenic bacterium can cause serious infectious diseases especially in hospitalized immuno-compromised patients. This bacterium is shown to be resistant against different antibiotics. Resistance against a wide range of antibiotics is usually mediated by efflux pump in bacteria. Efflux pumps are proteinaceous transporters localized in the cytoplasmic membrane of all kinds of cells which excreted antibiotics outside the cells. However, synthesis of new anti- Legionella compounds or selection of resistant modulating agents are useful strategy to combat with L. pneumophila in the future. Methods: In this study the antibacterial activity of some benzofuranone derivatives have been investigated by disk diffusion method against L. pneumophila . Also the sensitivity of this test strain was evaluated against 19 antibiotics and the combination effect of reserpine at a sub-inhibitory concentration was further studied with these antibiotics using disk diffusion method with some modifications. Co nclusion : Among the different synthetic compounds which were tested against L. pneumophila , the most antibacterial activity was observed for compounds 1j and 1m which contain hydroxyl and methoxy groups on the C-6 and C-7 positionsagainst L. pneumophila . To evaluate whether efflux pumps are active in L. pneumophila or not an efflux inhibitor (reserpine) was tested in combination of different antibiotics against this test strain. Reserpine significantly enhanced the antibacterial activities of kanamycin, nitrofurantoin, co-trimoxazole, erythromycin, ofloxacillin, gentamycin, rifampin, ciprofloxacin, nalidixic acid, minocycline, tobramycin, and amikacin against L. pneumophila which shows the resistances to these antibiotics are mediated by efflux system in this bacterium.
کلیدواژه‌های انگلیسی مقاله Reserpine, Legionella pneumophila, Anti-Bacterial Agents
نویسندگان مقاله محسن خالقی | mohsen khaleghi
department of pharmaceutical biotechnology and biotechnology research center, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

لطیفه نویدپور | latifeh navidpour
department of medicinal chemistry, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ضرغام sepehrizadeh | zargham sepehrizadeh
department of pharmaceutical biotechnology and biotechnology research center, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

پردیس نظری | pardis nazari
department of pharmaceutical biotechnology and biotechnology research center, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا پورمند | mohammadreza pourmand
department of pathobiology, school of public health, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نسرین صمدی | nasrin samadi
department of drug and food control and quality assurance research center, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید مجتبی موسویان | seyedmojtaba moosavian
department of microbiology, school of medicine and tropical research center, ahwaz jundishapour university of medical sciences, ahwaz, ir iran.


احمدرضا شاهوردی | ahmadreza shahverdi
department of pharmaceutical biotechnology and biotechnology research center, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://jmb.tums.ac.ir/index.php/jmb/article/view/38
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