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Journal of Medical Bacteriology، جلد ۱، شماره ۱-۲، صفحات ۹-۱۶
عنوان فارسی
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عنوان انگلیسی Prevalence of Methicillin-Resistant Staphylococcus aureus Carrying Panton-Valentine Leukocidin Gene in Cutaneous Infections in the City of Isfahan
چکیده انگلیسی مقاله Background: Methicillin-Resistant Staphylococcus aureus (MRSA) is a major cause of Nosocomial and community infections that are becoming increasingly difficult to combat, because of emerging resistance to all classes of antibiotics. Moreover Panton-Valentine leukocidin (PVL) is an important virulence factor in S. aureus and causes white blood cell destruction, necrosis and accelerated apoptosis. The aim of this study was to determine the frequency of PVL-positive MRSA in cutaneous infections, for epidemiological purposes and also to determine antibiotic resistance of the isolates. Methods: Collectively, 56 isolates of S. aureus were obtained from Isfahan University of Medical sciences affiliated hospitals and confirmed with biochemical tests (coagulase, mannitol fermentation, and DNase). Then polymerase chain reaction (PCR) was used to detect pvl gene. Coagulase gene was used as internal control. The antibiotic susceptibility of all isolates to methicillin was determined using disk diffusion method. Results: Out of 56 isolates 14.3% were PVL positive that 37.5% were from abscess and 62.5% were from wound. Among all of these isolates 67.8% were MRSA and also 75% of PVL-positive isolates were MRSA. Conclusion : The prevalence of PVL positive MRSA in cutaneous isolates is high. Future works are necessary for a more complete understanding of distribution of these virulent isolates in nasal carriers to decrease the risk of infections
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نویسندگان مقاله سولماز اوحدیان مقدم | solmaz ohadian moghadam
department of pathobiology, school of public health, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سیداصغر حوایی | seyedasghar havaei
department of microbiology, school of medicine, isfahan university of medical sciences, isfahan, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمدرضا پورمند | mohammadreza pourmand
department of pathobiology, school of public health, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://jmb.tums.ac.ir/index.php/jmb/article/view/5
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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