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Journal of Medical Bacteriology، جلد ۱، شماره ۱-۲، صفحات ۳۱-۳۷
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عنوان انگلیسی Effect of Amniotic Membrane Combined with Ciprofloxacin in Curing the Primary Stages of Pseudomonal Keratitis
چکیده انگلیسی مقاله Background : Keratitis caused by Pseudomonas aeruginosa is often resulted in severe corneal ulcers and perforation, which leads to losses of vision. Human amniotic membrane (HAM) forms the inner wall of the membranous sac which surrounds and protects the embryo during gestation. The purpose of this study was to evaluate the effectiveness of the amniotic membrane's healing in rabbits with pseudomonas keratitis. Methods : In total 14 rabbits divided in 2 groups of: 1 as Control and 2 as experimental amniotic membrane combined with ciprofloxacin. A 0.05 ml suspension of Pseudomonas aeruginosa ATCC 27853 was injected into rabbit’s corneal stroma, with no interference in control group. In the second group, the amniotic membrane in pieces of 1.5 × 1.5 cm transplanted to the entire corneal surface by eight interrupted 10.0 nylon sutures. In the first day ciprofloxacin drop was injected to the second group every 30 minutes and through second to seventh days every 2 hours. The results of perforation in cornea and the amount of infiltration were registered. Results : The results showed that amniotic membrane transplantation (AMT) + ciprofloxacin group had 0% perforation and the control group 85.6%. Average infiltrations were 5 mm in AMT + ciprofloxacin groups and 23.75 mm in control. Conclusion : The use of amniotic membrane with ciprofloxacin was effective in prevention of cornea perforation and controlling the process of pseudomonal keratitis remission. The improvement of inflammation rapidly happened in ciprofloxacin + AMT group.
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نویسندگان مقاله دکتر محمد مهدی سلطان دلال | mohammadmehdi soltan dallal
division of microbiology, department of pathobiology, school of public health, tehran university of medical sciences, tehran, ir iran and antibiotic resistant research center, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فرهاد نیکخواهی | farhad nikkhahi
division of microbiology, department of pathobiology, school of public health, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

صابر مولایی | saber molaei
eye research center, farabi eye hospital, tehran, ir iran.


کاظم حسینی | kazem hosseini
quality control manager of iranian tissue bank research amp;amp; preparation center, stem cells preparation unit., tehran, ir iran.


زهره کلافی | zohreh kalafi
division of microbiology, department of pathobiology, school of public health, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احد خوش زبان | ahad khoshzaban
eye research center, farabi eye hospital, tehran, ir iran.


عبدالعزیز رستگار لاری | abdolaziz rastegar lari
antibiotic resistant research center, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احمد خیرخواه | ahmad kheirkhah
eye research center, farabi eye hospital, tehran, ir iran and quality control manager of iranian tissue bank research amp;amp; preparation center, stem cells preparation unit., tehran, ir iran.


دکتر محمد کاظم شریفی یزدی | mohammadkazem sharifi yazdi
department of medical laboratory sciences, school of paramedicene, tehran university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://jmb.tums.ac.ir/index.php/jmb/article/view/9
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زبان مقاله منتشر شده en
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