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Iranian Journal of Blood and Cancer، جلد ۱۰، شماره ۴، صفحات ۱۱۴-۱۱۶
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عنوان انگلیسی Methylation Status of SMG1 Gene Promoter in Multiple Myeloma
چکیده انگلیسی مقاله Background: Epigenetic modifications, such as methylation can occur in multiple myeloma. SMG1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. In this study, we identified the methylation status of the SMG1 gene promoter in patients with multiple myeloma. Methods: Methylation status of SMG1 promoter in 9 patients with multiple myeloma and 4 healthy subjects as control was determined by Methylation-specific PCR (MSP) method. Results: SMG1 promoter in all myeloma patients was hemi-methylated. Meanwhile, in healthy subjects, two cases were hemi-methylated and the other two were normal. Conclusion: The results of this study indicated that the prevalence of SMG1 promoter methylation in patients with multiple myeloma was higher than general population which could be important in understanding the pathogenesis of the disease.
کلیدواژه‌های انگلیسی مقاله Multiple Myeloma, DNA methylation, SMG1 gene
نویسندگان مقاله | Hamid Gholipour
Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Saeid Abroun
Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Mehrdad Noruzinia
Hematology Department, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Sasan Ghaffari
Hematology Department, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Amirhosein Maali
Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran


| Mehdi Azad
Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-394-1&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/98/article-98-1153629.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Adults Hematology & Oncology
نوع مقاله منتشر شده پژوهشی
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