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Middle East Journal of Digestive Diseases، جلد ۱۱، شماره ۱، صفحات ۱۷-۲۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Clinical and Pathological Features of Ulcerative Colitis in Patients with and without Clostridium Difficile Infection; An Observational Study
چکیده انگلیسی مقاله BACKGROUND: A dramatic rise in the rate of clostridium difficile infection (CDI) in patients with inflammatory bowel disease (IBD) has been reported in recent years. METHODS: In this observational case control study, 65 patients were included and were divided into two groups of IBD+CDI as case group and IBD without CDI as control group. RESULTS: 35 patients who had positive test for clostridium difficile were assigned to the case group. The control group consisted of 30 patients with negative test for clostridium difficile. Pancolitis was seen in the cases more statistically significant than the controls and proctitis was seen more among the controls than the cases ( p =0.001). The cases were on immunosuppressive ( p =0.001) and antibiotic ( p =0.02) therapy more than the controls. Colonoscopic findings revealed more severe and extensive inflammation among the cases versus milder inflammation among the controls, but these differences were not statistically significant ( p =0.2). Colectomy was seen in 10% of controls and none of the cases and this difference was statistically significant ( p value=0.05). More fecal calprotectin were seen among the cases than the controls and this difference was statistically significant ( p < 0.05) CONCLUSION: This study showed more clostridium difficile infection among the patients on antibiotic or immunosuppressive therapy. Pathological investigation revealed more severe and extensive inflammation among the cases than the controls. Cases had clinically more severe signs and symptoms with higher mayo scores than the controls. ESR(erythrocyte sedimentation rate) and fecal calprotectin were higher in patients with positive clostridium difficile infection and serum albumin was lower in such patients.
کلیدواژه‌های انگلیسی مقاله Clostridium Difficile, Ulcerative Colitis, Infection
نویسندگان مقاله | Najmeh Aletaha
Tehran University of Medical Sciences; Imam Khomeini hospital; Division of gastroenterology and Hepatology


| Zohreh Dadvar
Shahid Beheshti University of Medical Sciences; Division of Gastroenterology and Hepatology


| Babak Salehi
Shahid Beheshti University of Medical Sciences; Division of Internal Medicine


| Pardis Ketabi Moghadam
Tehran University of Medical Sciences; Imam Khomeini hospital; Division of gastroenterology and Hepatology


| Ali Niksirat
Tehran University of Medical Sciences; Imam Khomeini hospital; Division of gastroenterology and Hepatology


| Akram Jowkar
Tehran University of Medical Sciences; Imam Khomeini hospital; Division of gastroenterology and Hepatology


| Reza Taslimi
Tehran University of Medical Sciences


| Seyed Farshad Allameh
Tehran University of Medical Sciences; Imam Khomeini hospital; Division of gastroenterology and Hepatology


| Naser Ebrahimi Daryani


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/1971
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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