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International Journal of Fertility and Sterility، جلد ۱۲، شماره ۴، صفحات ۳۰۶-۳۰۹
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عنوان انگلیسی Significant Correlation between High-Risk HPV DNA in Semen and Impairment of Sperm Quality in Infertile Men
چکیده انگلیسی مقاله Objective: Background: Human papillomavirus (HPV) is a DNA virus that causes sexually transmitted infection (STI). Recent reports have suggested that HPV may affect sperm parameters and lead to male infertility. This study is aimed to evaluate the correlation between seminal high-risk HPV infection and impairment of sperm quality in Iranian infertile men. Materials and methods: Materials and Methods: In this case-control study, fresh semen samples of 70 fertile men and 70 confirmed infertile men, referred to Yazd infertility center in 2015, were collected. Semen analyses were performed according to the World Health Organization (WHO) guidelines. High-risk HPV DNA was detected by real-time PCR method. Results: A total of 140 subjects were participated in the current study. Among 70 confirmed infertile males, only 8 cases were positive for high-risk HPV (11.43℅) and all fertile men were HPV-negative. This data revealed a significant association between high-risk HPV and male infertility (p=0.03). Percentage of normal sperm morphology and sperm motility rate were significantly declined in men infected with HPV (< 0.001). Results: Results: A total of 140 subjects were participated in the current study. Among 70 confirmed infertile males, only 8 cases were positive for high-risk HPV (11.43℅) and all fertile men were HPV-negative. This data revealed a significant association between high-risk HPV and male infertility (p=0.006). Percentage of normal sperm morphology and sperm motility rate were significantly declined in men infected with HPV (p< 0.05). Conclusion: Conclusion: The prevalence of high-risk HPVs in infertile men was significantly higher than fertile man. HPV infection seems to be a risk factor for male infertility. Further larger studies are required to confirm the impact of HPV on male infertility.
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نویسندگان مقاله | Mansour Moghimi


| Somayeh Zabihi-Mahmoodabadi


| Aliasghar Kheirkhah-Vakilabad


| Zahra Kargar


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/5421
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