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Journal of Pharmaceutical Care، جلد ۱، شماره ۴، صفحات ۱۴۹-۱۵۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Vancomycin Utilization Evaluation: Are We Dosing Appropriately?
چکیده انگلیسی مقاله Background : Inappropriate use of vancomycin not only increase health care costs but also contribute to the emergence of resistant organisms. Higher trough serum vancomycin concentrations (>10mg/L) has been recommended for avoidance of development of resistance. We aim to compare the administered dose with recommended doses based on guideline-recommended weight-based dosing. Methods : In a cross sectional study, all patients who received vancomycin between July and October 2013, in infectious disease, internal medicine wards and emergency department of a teaching hospital in Tehran, Iran were entered to the study. Indication of vancomycin and necessary data for dose calculation including height and serum creatinine were recorded. Prescribed doses were compared with recommended doses in guidelines and calculated Glomerular filtration rate (GFR) for each patient. Results : One hundred and four patients (45 females and 59 males) recruited in the study. Our results indicated that, from all administered doses of vancomycin, 64.4% and 88.8% differs significantly (more than 20%) based on American Pharmacist Association (AphA) vancomycin monograph and guideline-recommended, weight-based vancomycin dosing (for adults), respectively. Conclusion : Underdosing of vancomycin is a major risk factor for developing resistance of gram positive organisms to this glycopeptide. Our results showed that more than half of patients receiving vancomycin are in the risk of low drug levels based on guidelines. So, having a comprehensive plan for the proper use of this drug especially designing effective internal guidelines can prevent emergence of resistance to vancomycin in future.
کلیدواژه‌های انگلیسی مقاله Vancomycin,Guideline,Weight,Dosing
نویسندگان مقاله لادن ayazkhoo | ladan ayazkhoo
department of clinical pharmacy, faculty of pharmacy,shahid beheshti university of medical sciences, tehran, iran and pharmaceutical care unit, emam hossein teaching and educational center, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

سارا موسوی | sarah mousavi
department of clinical pharmacy and pharmacy practice, faculty of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فرناز رمضانی | farnaz ramazani
department of clinical pharmacy, faculty of pharmacy,shahid beheshti university of medical sciences, tehran, iran and pharmaceutical care unit, emam hossein teaching and educational center, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مریم آیت اللهی تفتی | maryam ayatollahi tafti
department of clinical pharmacy, faculty of pharmacy,shahid beheshti university of medical sciences, tehran, iran and pharmaceutical care unit, emam hossein teaching and educational center, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

زینب sa dabadi | zeinab sa dabadi
department of clinical pharmacy, faculty of pharmacy,shahid beheshti university of medical sciences, tehran, iran and pharmaceutical care unit, emam hossein teaching and educational center, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

محمد سیستانی زاد | mohammad sistanizad
department of clinical pharmacy, faculty of pharmacy,shahid beheshti university of medical sciences, tehran, iran and pharmaceutical care unit, emam hossein teaching and educational center, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://jpc.tums.ac.ir/index.php/jpc/article/view/33
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