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Journal of Pharmaceutical Care، جلد ۱، شماره ۲، صفحات ۴۱-۴۴
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کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparison of efficacy and tolerability of different brands of amlodipine in patients with mild to moderate hypertension
چکیده انگلیسی مقاله Background: The efficacy of amlodipine, a calcium channel blocker, in treating systemic hypertension is well established but the most efficacious brand of this drug is still uncertain. The cost of different brands of amlodipine is tremendously different which may affect decision-making in hypertension treatment. The purpose of this study was to compare the efficacy and safety of different brands of amlodipine (Amlodipine, Amlopress, and Norvasc) in the treatment of hypertension in adult patients. Methods: This was a double-blind, randomized, three-sequence crossover study. Ambulatory patients with hypertension who had the inclusion criteria were enrolled. Patients were randomized and entered into three groups to receive either brand of amlodipine in a crossover method. After every four weeks of treatment completed, the other brand of drug was prescribed. The total period of the study was 12 weeks for all three drugs including four weeks for each brand. Results: A total of 20 patients entered to the study, 15 completed the 12-week treatment schedule. The absolute reductions in seated and supine systolic blood pressure (SBP) and diastolic blood pressure (DBP) were similar with all three brands during the 4 weeks of treatment. Headache, malaise and weakness were the most common reported adverse effects (AE) with all three drugs. Generic amlodipine had the most AE as compared with other brands. These AE were mild and did not require withdrawal of the drug. Conclusion: There is no statistical difference in lowering blood pressure by three different brands of amlodipine thus everyone which has the lowest price can be the first choice.
کلیدواژه‌های انگلیسی مقاله Amlodipine,Amlopress,Norvasc,Hypertension
نویسندگان مقاله ملوک حاجی بابایی | molouk hadjibabaie
department of clinical pharmacy, and research center for rational use of drugs, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سیدحمید خویی | seyedhamid khoee
department of clinical pharmacy, and research center for rational use of drugs, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ابراهیم nematipoor | ebrahim nematipoor
department of cardiology, faculty of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

خیراله غلامی | kheirollah gholami
department of clinical pharmacy, and research center for rational use of drugs, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

افسانه فتاحیان | afsaneh fatahian
department of clinical pharmacy, and research center for rational use of drugs, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

زهرا جهانگرد | zahra jahangard
department of clinical pharmacy, and research center for rational use of drugs, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://jpc.tums.ac.ir/index.php/jpc/article/view/10
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