این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Pharmaceutical Care، جلد ۱، شماره ۲، صفحات ۴۵-۵۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Propolis attenuates oxidative injury in brain and lung of nitric oxide synthase inhibited rats
چکیده انگلیسی مقاله Background: The blocking of nitric oxide synthase (NOS) activity may reason vasoconstriction with formation of reactive oxygen species. Propolis has biological and pharmacological properties, such as antioxidant. The aim of this study was to examine the antioxidant effects of propolis which natural product on biochemical parameters in brain and lung tissues of acute nitric oxide synthase inhibited rats by Nω-nitro-L-arginine methyl ester (L-NAME). Methods: Rats have been received L-NAME (40 mg/kg, intraperitoneally), NOS inhibitor for 15 days to produce hypertension and propolis (200mg/kg, by gavage) the lastest 5 of 15 days. Results: There were the increase ( P < 0.001) in the malondialdehyde levels in the L-NAME treatment groups when compared to control rats, but the decrease ( P < 0.001) in the catalase activities in both brain and lung tissues. There were statistically changes ( P < 0.001) in these parameters of L-NAME+propolis treated rats as compared with L-NAME-treated group. Conclusion: The application of L-NAME to the Wistar rats resulted in well developed oxidative stress. Also, propolis may influence endothelial NO production. Identification of such compounds and characterisation of their cellular actions may increase our knowledge of the regulation of endothelial NO production and could provide valuable clues for the prevention or treatment of hypertensive diseases and oxidative stress.
کلیدواژه‌های انگلیسی مقاله Catalase,L-NAME,Malondialdehyde,Oxidative,stress,PropolisRat
نویسندگان مقاله zeliha selamoglu talas | zeliha selamoglu talas
department of biology, faculty of arts and sciences, nigde university, nigde, 51200 turkey


ilknur ozdemir | ilknur ozdemir
department of chemistry, faculty of arts and sciences, inonu university, malatya, 44280 turkey


عثمان ciftci | osman ciftci
department of pharmaceutical toxicology, faculty of pharmacy, inonu university, malatya, 44280 turkey


oguz cakir | oguz cakir
department of chemistry, faculty of arts and sciences, dicle university, diyarbakir, turkey
نشانی اینترنتی http://jpc.tums.ac.ir/index.php/jpc/article/view/11
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article(s)
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات