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Journal of Pharmaceutical Care، جلد ۱، شماره ۱، صفحات ۳-۷
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عنوان انگلیسی The incidences of oxidative-stress occurrence following two metabolic support measures in critically ill patients
چکیده انگلیسی مقاله Background: A high percentage of patients admitted to the Intensive Care Unit (ICU) have Systemic Inflammatory Response Syndrome (SIRS) criteria. Free radicals play an important role in initiation and development of SIRS. The purpose of this study was to assess and compare the molecular changes of cellular antioxidant power in patients with SIRS who received enteral nutrition (EN) or EN combined with parenteral nutrition (PN). Methods: Two groups of 10 patients were enrolled in this randomized, controlled clinical trial. Those in the treatment group received EN+PN and the control group received only EN. Venous blood samples were taken just prior to initiation of nutritional support and then 24, 48 and 72 hours following entry into the study for examination of antioxidant parameters including total thiol, total antioxidant capacity and lipid peroxidation. Results: The two supportive regimens had different affects on total antioxidant capacity (P=0.005). In the EN group the amount of total antioxidant capacity was not significantly different in different days (P>0.05), but in the EN+PN group it was significantly different on third and forth days as compared to the first day. The two other parameters had no significant differences between the two groups. Conclusion: These results are suggesting that an increase in oxidative stress bio- markers are not necessarily related to the route of pharmaconutrition and may occurindependently during metabolic support measures.
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نویسندگان مقاله آسیه موسیوند | asie moosivand
faculty of pharmacy and pharmaceutical sciences, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

رامین ابریشمی | ramin abrishami
pharmaceutical research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد عبداللهی | mohammad abdollahi
faculty of pharmacy and pharmaceutical sciences, tehran university of medical sciences, tehran, iran and pharmaceutical research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آرزو احمدی | arezoo ahmadi
school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مجتبی مجتهدزاده | mojtaba mojtahedzadeh
faculty of pharmacy and pharmaceutical sciences, tehran university of medical sciences, tehran, iran and pharmaceutical research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://jpc.tums.ac.ir/index.php/jpc/article/view/2
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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