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The Archives of Bone and Joint Surgery، جلد ۲، شماره ۱، صفحات ۱۷-۲۴
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عنوان انگلیسی Effects of Valproic Acid on Axonal Regeneration and Recovery of Motor Function after Peripheral Nerve Injury in the Rat
چکیده انگلیسی مقاله Background: Valproic acid (VPA) is used to be an effective anti-epileptic drug and mood stabilizer. It has recently been demonstrated that VPA could promote neurite outgrowth, activate the extracellular signal regulated kinase pathway, and increases bcl-2 and growth cone-associated protein 43 levels in spinal cord. In the present research we demonstrate the effect of VPA on peripheral nerve regeneration and recovery of motor function following sciatic nerve transaction in rats. Methods: The rats in VPA group and control group were administered with valproic acid (300mg/kg) and sodium chloride respectively after operation. Each animal was observed sciatic nerve index (SFI) at 2-week intervals and studied electrophysiology at 4-week intervals for 12 weeks. Histological and morphometrical analyses were performed 12 weeks after operation. Using the digital image-analysis system, thickness of the myelin sheath was measured, and total numbers of regenerated axons were counted. Results: There was a significant difference in SFI, electrophysiological index (motor-nerve conduct velocity), and morphometrical results (regenerated axon number and thickness of myelin sheath) in nerve regeneration between the VPA group and controls ( P< 0.05). Conclusions: The results demonstrated that VPA is able to enhance sciatic nerve regeneration in rats, suggesting the potential clinical application of VPA for the treatment of peripheral nerve injury in humans.
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نویسندگان مقاله ting رایو | ting rao
department of urology people hospital of wuhan university, wuhan city hu bei province, people’s republic of china


fei wu | fei wu
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china


danmou xing | danmou xing
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china


zhengren peng | zhengren peng
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china


دانک ren | dong ren
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china


wei feng | wei feng
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china


یان chen | yan chen
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china


zhiming zhao | zhiming zhao
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china


huan ونگ | huan wang
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china


junweng ونگ | junweng wang
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china


wusheng کند | wusheng kan
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china


qingsong زانگ | qingsong zhang
department of hand surgery and microsurgery pu ai hospital of huazhong university of science and technology, wuhan city, hu bei province people’s republic of china
نشانی اینترنتی http://abjs.mums.ac.ir/article_2367.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده RESEARCH PAPER
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