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International Journal of Radiation Research، جلد ۱۶، شماره ۴، صفحات ۴۸۱-۴۸۵
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Peri-operative radiotherapy for the prevention of post-operative fibrosis on rats
چکیده انگلیسی مقاله Background: Post-operative fibrosis related pains and functional anomalies  can be serious problems for patients. Radiotherapy (RT) could inhibit fibrosis which may occurs post- operation especially following laminectomy. Therefore, this study was designed to investigate the effect of peri-operative RT on the prevention of post-operative fibrosis and scar formation on rats. Materials and Methods: Twenty three male Wistar albino rats,  were divided into three experimental groups. Laminectomy was performed to L3 and L4 lomber vertebral regions of group L and L+R rats. The rats in L+R group  in addition to this procedure also received peri-operative RT on the laminectomy area. A total dose of 700 cGy of RT was applied as a single fraction  using electrons. Control rats received no treatment. A rotarod test was performed at 20, 30 and 40 rpm/min speed rates to determine the physical performances of the rats. Results: The results have indicated statistically significant (P< 0.05) differences for the 30 rpm/min rotarod test between the L and L+R groups. Histopatologically, significant differences were observed in epidural fibrosis, fibroblast cell density and arachnoid adhesion between the L and L+R groups. Conclusion: It was concluded that peri-operative RT may provide a significant advantage for prevention post-laminectomic of scar tissue formation.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | H.S. Kiziltan
Department of Radiation Oncology, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey


| A.H. Eris
Department of Radiation Oncology, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey


| I. Meral
Department of Physiology, Faculty of Medical, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey


| H. Seyithanoglu
Department of Neurosurgery, Bezmialem Vakif University 34093 Faculty of Medical, Fatih, Istanbul, Turkey


| T. Dundar
Department of Neurosurgery, Bezmialem Vakif University 34093 Faculty of Medical, Fatih, Istanbul, Turkey


| F. Eren
Department of Physical Therapy and Rehabilitation, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey


| N. Unver
Department of Pathology, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey


| T. Aydin
Department of Physical Therapy and Rehabilitation, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey


| A. Mayadagli
Department of Radiation Oncology, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey


| A.G. Bayir
Department of Nutrition and Dietetics, Bezmialem Vakif University Faculty of Medical, 34093 Fatih, Istanbul, Turkey


| M. Celikten
Department of Animal Scientific Research Center, Bezmialem Vakif University Medical Faculty 34093 Fatih, Istanbul, Turkey
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-747&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/42/article-42-1167389.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده مرور و بررسی کلی
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