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Iranian Journal of Pediatric Hematology and Oncology، جلد ۹، شماره ۱، صفحات ۳۲-۳۹
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عنوان انگلیسی Pubertal status and its relation with serum ferritin level in thalassemia major patients
چکیده انگلیسی مقاله Background: Thalassemia major (TM) is one of the most common hereditary anemia with multiple endocrinopathies (especially hypogonadism). So, we evaluated the rate of delayed puberty (DP) and its relation with serum ferritin level in patients. Materials and Methods: This cross-sectional (descriptive-analytical) study was conducted on 100 patients with TM between 14-64 years old, admitted to Amirkola Thalassemia Center, Babol, Iran, in 2016. The pubertal status, (Marshall-Tanner scale), existance of DP, and its different types were evaluated. Mean serum ferritin level was measured and the data were classified to three groups of < 1500, 1500-2500, and >2500 ng/ml. Data were analyzed using SPSS (version20). Results: Out of 100 patients, 64 (64%) and 36 (36%) were female and male, respectively. Considering age, 23, 77 patients (%) were under and over 20 years old, respectively. Totally, 69 (69%) of them had DP, of whom 64 (92.8%) ones had secondary (central) hypogonadotropic hypogonadism. Mean serum ferritin level (±SD) was 2707.94±1683.42 ng/ml. In addition, 26, 29, and 45 patients had ferritin level < 1500, 1500-2500, and >2500 ng/ml, respectively. Thirty two patients with DP (46.4%) had ferritin level above 2500 ng/ml (p-value= 0.623). Conclusion: The results showed a high frequency of DP in TM patients, requiring careful examination and follow-up in terms of puberty for early diagnosis and proper treatment to improve their quality of life, and prevention of the complications like osteoporosis. We couldn't find any significant relationship between serum ferritin level and hypogonadism, even for cases who received enough iron chelators.  
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نویسندگان مقاله | Morteza Alijanpour Aghamaleki
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran.


| Ahmad Tamaddoni
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran.


| Hassan Mahmoodi Nesheli
The Clinical Research Development Unit of Amirkola Children&apos;s Hospital, Babol University of Medical Sciences, Babol, IR Iran.


| Mahmoud Hajiahmadi
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran.


| Mahmoud Hajiahmadi
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran.


| Motahareh Amouzadeh Samakoush
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.


| Faeze Aghajanpour
MSc (student) of Statistics, Department of Statistics, University of Mazandaran, Babolsar, Iran.
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-654-2&slc_lang=fa&sid=1
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زبان مقاله منتشر شده fa
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