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International Journal of Fertility and Sterility، جلد ۱۳، شماره ۱، صفحات ۱۸-۲۳
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عنوان انگلیسی Effect of Vitamin D Supplementation on Intracytoplasmic Sperm Injection Outcomes: A Randomized Double-Blind Placebo-Controlled Trial
چکیده انگلیسی مقاله Objective: Despite numerous studies indicating an imperative role for reproduction, however, the role of Vitamin D supplementation on outcomes of assisted reproductive techniques remains controversial. Therefore, the objective of this clinical trial was to evaluate the effect of consumption of Vitamin D supplementation 6 weeks prior to ICSI on fertility indexes. Materials and methods: The present study was a double-blind clinical trial conducted on infertile women was randomly allocated into two groups: Vitamin D supplementation (42 participants) and placebo (43 participants). Serum Vitamin D was measured before and six to eight weeks after treatment, on the day of ovum pick up. Results were analyzed using SPSS16 and fertility indexes were compared between the two groups. Results: No significant difference was observed between the intervention and control groups regarding the mean number of oocytes retrieved, percentage mature oocyte, fertilization rate and the rate of good quality embryos (p > 0.05). But, percentages of the individual with suitable endometrium (triple line and 7-14 mm thickness) were significantly higher in the Vitamin D compared to control group. The rate of early pregnancy sign defined by βhCG (47.6% vs. 25.5 %, P< 0.05) and clinical (38.1% vs. 20.9%, P< 0.05) pregnancy rate were also significantly higher in the Vitamin D compared to control group. Conclusion: The present study reveals that consuming Vitamin D for 6 weeks prior to ICSI improves quality of endometrium and rate of clinical pregnancy.
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نویسندگان مقاله | Sara Abedi


| Mahboubeh Taebi


| Mohammad Hossein Nasr-Esfahani


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/5470
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