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Middle East Journal of Digestive Diseases، جلد ۸، شماره ۳، صفحات ۱۷۹-۰
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عنوان انگلیسی The Effect of Probiotic Plus Prebiotic Supplementation on the Tolerance and Efficacy of Helicobacter Pylori Eradication Quadruple Therapy: a Randomized Prospective Double Blind Controlled Trial
چکیده انگلیسی مقاله BACKGROUND Standard anti- Helicobacter pylori ( H. pylori ) treatment fails in the eradication of the organism in almost 10-35% of the patients and has different side effects. Recent studies have proposed that probiotic supplementations with or without prebiotic may improve the eradication rate and diminish the side effects, although it is still a controversial issue. We aimed to investigate the effect of probiotic with prebiotic supplementation on the eradication rate and side effects of anti H. pylori quadruple therapy. METHODS 76 patients with a positive biopsy specimen for H. pylori were enrolled. They were randomized to receive quadruple therapy of bismuth, clarithromycin, amoxicillin, and omeprazole for 14 days and also the synbiotic or the placebo. We asked them to answer study questionnaires at the beginning and during the treatment. Finally, urea breath test was done 8 weeks after the treatment. RESULTS The eradication rate was significantly better in the synbiotic group by intention-to-treat analysis ( p < 0.05). Treatment side effects such as diarrhea, nausea, vomiting, epigastric pain, flatulence, constipation, and taste abnormality were similar in both groups but anorexia was significantly better in the synbiotic group ( p < 0.05) CONCLUSION In this study, the synbiotic supplementation did not diminish the frequency of symptoms during H. pylori eradication treatment but could improve the eradication by augmenting the treatment tolerance and compliance.
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نویسندگان مقاله افشین شفقی | afshin shafaghi


آیدین پورکاظمی | aydin pourkazemi


محسن خسروانی | mohsen khosravani


صبا فخریه اصل | saba fakhrie asl


علیرضا امیر معافی | alireza amir maafi


زهرا عطرکار روشن | zahra atrkar roshan


جعفر عباسپور rahimabad | jafar abaspour rahimabad


نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/1639
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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