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Middle East Journal of Digestive Diseases، جلد ۸، شماره ۳، صفحات ۲۱۹-۰
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عنوان انگلیسی A Comparison between Hybrid and Concomitant Regimens for Helicobacter Pylori Eradication: A Randomized Clinical Trial
چکیده انگلیسی مقاله BACKGROUND Helicobacter pylori (H. pylori) is one of the most common bacterial infections worldwide. We designed a study to compare the efficacy of 14-day hybrid regimen with 10-day concomitant therapy for H. pylori eradication in Iran. METHODS 252 patients with naïve H. pylori infection were randomly divided to receive either hybrid regimen (pantoprazole 40 mg, and amoxicillin 1 gr twice daily for 14 days, accompanied by clarithromycin 500 mg, and metronidazole 500 mg, twice daily just during the last 7 days) or concomitant regimen (pantoprazole 40 mg, amoxicillin 1 gr, clarithromycin 500 mg, and metronidazole 500 mg, all twice daily for 10 days). 8 weeks after therapy, 14 C- urease breath test was performed to confirm eradication. RESULTS According to intention to treat analysis, the eradication rates were 87.3% (95% CI: 81.4–93.1) and 80.9% (95% CI: 74-87.8) in hybrid and concomitant groups, respectively ( p =0.38). Per-protocol eradication rates were 89.3% (95% CI: 83.8-94.7) and 83.1% (95% CI: 76.3-89.8), respectively ( p =0.19). The rates of severe side effects were not statistically different between the two groups (4% vs. 8.7%). CONCLUSION 14-day hybrid therapy can be considered as a nearly acceptable regimen with few severe side effects in Iran. However, it seems that the efficacy of this therapy is decreasing as the resistance rates to antibiotics are increasing. We suggest further studies to assess the efficacy of a more prolonged concomitant therapy for H. pylori eradication in Iran.
کلیدواژه‌های انگلیسی مقاله Helicobacter Pylori,Eradication,Hybrid regimen
نویسندگان مقاله سامان الهویی | saman alhooei


حافظ تیرگر فاخری | hafez tirgar fakheri


وحید حسینی | vahid hosseini


ایرج ملکی | iradj maleki


ترنگ تقوایی | tarang taghvaei


سید محمد ولی زاده | seyed mohammad valizadeh


زهره باری | zohreh bari


نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/1646
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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