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Middle East Journal of Digestive Diseases، جلد ۸، شماره ۱، صفحات ۳۹-۰
عنوان فارسی
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عنوان انگلیسی A Comparison between Hybrid Therapy and Standard Triple Therapy for Helicobacter pylori Eradication in Patients with Uremia: A Randomized Clinical Trial
چکیده انگلیسی مقاله BACKGROUND The prevalence of peptic ulcer disease in hemodialysis patients is more than the general population. They are also more prone to complications including upper gastrointestinal bleeding. The aim of this study was to compare the efficacy of 14 days hybrid regimen with 14 days triple therapy for Helicobacter pylori ( H . pylori ) eradication in hemodialysis patients. METHODS Forty hemodialysis patients with naïve H . pylori infection were randomized to receive either hybrid regimen (pantoprazole 40 mg + amoxicillin 500 mg, both twice a day during the first 7 days, followed by pantoprazole 40 mg + amoxicillin 500 mg + clarithromycin 500 mg + tinidazole 500 mg, all twice a day, for the second 7 days, or standard triple therapy including pantoprazole 40 mg, clarithromycin 500 mg, and amoxicillin 500 mg, all twice a day for 14 days. H. pylori eradication was assessed by fecal H . pylori antigen test 8 weeks after the treatment. RESULTS All the patients completed the study. According to both intention to treat and per-protocol analyses, H . pylori eradication rates were 100% (95% confidence interval (CI): 100) in those who received hybrid therapy and 70% (95% CI: 69.4 – 70.8) in those who were treated by standard triple therapy ( p =0.02). Severe adverse effects were not reported by any patient; however, mild adverse effects were more frequent in those who received standard triple therapy ( p < 0.05). CONCLUSION Hybrid regimen could achieve ideal H . pylori eradication rates with low rates of adverse effects.
کلیدواژه‌های انگلیسی مقاله Hybrid, Hemodialysis, Helicobacter pylori
نویسندگان مقاله عطیه مخلوق | atieh makhlough
associate professor of nephrology, inflammatory diseases of the upper gastrointestinal tract research center, imam hospital, sari, iran


حافظ فاخری | hafez fakheri
professor of gastroenterology, inflammatory diseases of the upper gastrointestinal tract research center, imam hospital, sari, iran.


سمانه حجتی | samaneh hojati


وحید حسینی | vahid hosseini


زهره باری | zohreh bari
fellow of gastroenterology, mazandaran university of medica sciences, sari, iran.

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/1458
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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