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Middle East Journal of Digestive Diseases، جلد ۸، شماره ۱، صفحات ۴۴-۰
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عنوان انگلیسی Expression of P33ING1b protein in Colorectal Cancer
چکیده انگلیسی مقاله BACKGROUND Colorectal cancer (CRC) is the second most common malignancy in the world. However, its mortality rate can be reduced if diagnosed early. P33 ING1b is a tumor suppressor protein, which plays a role in growth control and apoptosis. Suppression of p33 ING1b is associated with the loss of cellular growth control. However, p33 ING1b expression in CRC and its correlations with clinicopathological factors have been less studied. The aim of this study was to examine p33 ING1b expression in patients with CRC and evaluate its potential correlations with clinicopathological factors. METHODS P33 ING1b protein expression was examined in 70 cases of CRC tissue samples and their corresponding neighboring normal tissues by immunhistochemistry. Moreover, p33 ING1b expression in CRC and its correlations with clinicopathological variables including patients’ sex and age, tumor type, location, stage, and differentiation grade were examined. RESULTS P33 ING1b expression was significantly lower in tumor samples compared with the normal adjacent samples ( p < 0.002). CONCLUSION Low expression of P33 ING1b in patients with colorectal cancer, may be an important molecular event in the pathogenesis of colorectal cancer. Our data suggest that reduced expression of p33 ING1b may be contribute to tumor genesis and accompanied by the loss of cellular growth control. In fact cell growth is out of control in lower expression of P33 and dysfunctional program cell death. P33 expression might explain the etiology of CRC for reducing the expression of tumor suppressor proteins.
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نویسندگان مقاله سمیه فلاح نژاد | somaye fallahnezhad


مهدی نیکبخت | mehdi nikbakht


سعید شکری | saeed shokri


نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/1587
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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