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Cell Journal، جلد ۲۰، شماره ۰۴، صفحات ۴۸۳-۴۹۵
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عنوان انگلیسی Systemic Infusion of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells in Peritoneal Dialysis Patients: Feasibility and Safety
چکیده انگلیسی مقاله Objective: Objective: Mesenchymal stem cells (MSCs) are regarded as a new approach for improving fibrotic disease. Here we aimed to evaluate the feasibility, and safety of systemic infusion of autologous adipose tissue derived MSCs (AD-MSCs) in peritoneal dialysis (PD) patients with expected peritoneal fibrosis. Materials and methods: Materials and Methods: This study was a prospective, open label, non-randomized, without placebo, phase I clinical trial (IRCT2015052415841N2). Case group was consisted of nine eligible PD patients with more than two years history of being on PD. Autologous AD-MSCs were obtained through lipoaspiration and expanded under good manufacturing practice conditions. Patients received 1.2 ± 0.1*106 cell/kg of AD-MSCs via cubital vein and then were followed for six months at time points of baseline, and then 3 weeks, 6 weeks, 12 weeks, 16 weeks and 24 weeks after infusion. Clinical, biochemical and peritoneal equilibration test (PET) were performed to assess the safety and probable change in peritoneal solute transport parameters. Results: Results: No serious adverse events and no catheter related complications were found. 14 minor adverse events reported were self-limited or subsided after supportive treatment. Two patients developed one episode of peritonitis and one exit site infection which did not appear to be related to the procedure. A significant decrease in rate of solute transport across peritoneal membrane detected by PET was observed (D/P cr=0.77 vs 0.73, P=0.02). Conclusion: Conclusion: This study, for the first time, showed the feasibility and safety of AD-MSCs in PD patients and possible positive changes in solute transport. There is certainly a need for further studies with larger samples, longer follow-up, and randomized blind control groups to elucidate the most effective route, frequency and dose of MSCs administration.
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نویسندگان مقاله | Sudabeh Alatab


| Soroosh Shekarchian


| Iraj Najafi


| Reza Moghadasali


| Naser Ahmadbeigi


| Mohammad Reza Pourmand


| Tina Bolurieh


| Neda Jaroughi


| Gholamreza Pourmand


| Nasser Aghdami


نشانی اینترنتی https://celljournal.org/journal/article/abstract/5591
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