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Cell Journal، جلد ۲۰، شماره ۰۴، صفحات ۵۲۱-۵۲۶
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عنوان انگلیسی Effect of Zinc on Spermatogenesis and Sperm Chromatin Condensation in Bleomycin, Etoposide, Cisplatin Treated Rats
چکیده انگلیسی مقاله Objective: of bleomycin, etoposide and cisplatin (BEP) increased survival rate of patients with testicular cancer. Although BEP is one of the most effective treatment for testicular cancer but BEP treatment is accompanied by severe disorders on reproductive system that ultimately leads to infertility. Zinc has an important role in progression of spermiogenesis, in addition to its antioxidant activity. This study aimed to evaluate effect of zinc on sperm parameters, chromatin condensation and testicular structure after BEP treatment. Materials and methods: In this experimental study, 40 male rats divided into 4 groups (control, BEP, BEP+ zinc and zinc) and examined for 2 spermatogenesis periods (18 weeks). The rats in BEP and BEP+ zinc group were treated with chemotherapeutic agents of BEP at appropriate dose levels of BEP (0.75, 7.5, and 1.5 mg/kg, respectively) for three cycles of three weeks. Dose of zinc in BEP+ zinc and zinc group was 10mg/kg/day. After 18 weeks, we assessed excessive histones in sperm chromatin through aniline blue staining, testicular structure and germ line cells through Periodic Acid Schiff staining, also sperm motility and morphology. Results: AResults: After BEP treatment, significant decrease observed in normal sperm morphology, motility, concentration, alterations on rat sperm chromatin condensation and testicular tissue (p< 0.001). Furthermore after zinc consumption for 9 weeks, we observed significant recovery of sperm parameters and chromatin condensation, also a significant retrieval on spermatogonia, leydig cells and tubular architecture (p< 0.05). Conclusion: Zinc administration after chemotherapy with BEP in testicular cancer might be potentially useful in declining the off target consequence associated with oxidative stress.
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نویسندگان مقاله | Shahnaz Razavi


| Farnaz Khadivi


| Fatemeh Hashemi


| Abbas Bakhtiari


نشانی اینترنتی https://celljournal.org/journal/article/abstract/5522
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