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Middle East Journal of Digestive Diseases، جلد ۷، شماره ۲، صفحات ۷۵-۰
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عنوان انگلیسی Efficacy of Clarithromycin Containing Bismuth–Based Regimen as a Second-Line Therapy in Helicobacter Pylori Eradication
چکیده انگلیسی مقاله BACKGROUND: The eradication of Helicobacter pylori infection, commonly prevailing in the stomach, has been important since its introduction. Adequate preparations should be made in finding alternatives when faced with first-line treatment failures. Currently, ideal second-line treatments are indistinct and varied among countries as result of different antibiotic resistance patterns. We aimed to evaluate the safety and efficacy of a clarithromycin-containing bismuth-based quadruple regimen as a second-line treatment. METHODS: Forty-eight H. pylori -positive patients with proven gastric or duodenal ulcers and/or erosions who had previously failed to respond to furazolidone-containing regimens were enrolled. They received pantoprazole (40 mg-bid), amoxicillin (1 g-bid), bismuth subcitrate (240 mg-bid), and clarithromycin (500mg-bid) for 10 days. Eight weeks after treatment, a 14 C-urea breath test was performed for the re-evaluation of H. pylori eradication. RESULTS: Forty-three patients completed the study. H.pylori eradication rates were 79.2% (95% CI=65.00-89.53) and 88.4% (95% CI=74.91-96.11) according to intention-to-treat and per-protocol analyses, respectively. All patients had excellent compliance to treatment and one did not continue therapy because of adverse effects. CONCLUSION: In developing countries such as Iran, a ten-day clarithromycin-containing bismuth-based quadruple regimen is encouraged as a second-line treatment because of the acceptable rate of eradication and low adverse effects.
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نویسندگان مقاله مرجان مخترع | marjan mokhtare
inflammatory disease of the upper gastrointestinal tract research center,mazandaran university of medical sciences,sari,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

شهرام آگاه | shahram agah
colorectal research center,iran university of medical sciences,tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

حافظ فاخری | hafez fakheri
inflammatory disease of the upper gastrointestinal tract research center,mazandaran university of medical sciences,sari,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

وحید حسینی | vahid hosseini
inflammatory disease of the upper gastrointestinal tract research center,mazandaran university of medical sciences,sari,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

سید محمد صادق غفوری | seyed mohammad sadegh ghafoori
colorectal research center,iran university of medical sciences,tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

محسن رضایی همامی | mohsen rezaei hemami
colorectal research center,iran university of medical sciences,tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/1417
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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