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Middle East Journal of Digestive Diseases، جلد ۶، شماره ۲، صفحات ۶۵-۰
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عنوان انگلیسی Gastroesophageal Reflux Disease and overall and Cause-specific Mortality: A Prospective Study of 50000 Individuals
چکیده انگلیسی مقاله BACKGROUND Only a few studies in Western countrieshave investigated the association between gastroesophageal reflux disease(GERD) and mortality at the general population level and they have shown mixedresults. This study investigated the association between GERD symptoms andoverall and cause-specific mortality in a large prospective population-based studyin Golestan Province, Iran. METHODS Baseline data on frequency, onset time,and patient-perceived severity of GERD symptoms were available for 50001participants in the Golestan Cohort Study (GCS). We identified 3107 deaths(including 1146 circulatory and 470 cancer-related) with an average follow-upof 6.4 years and calculated hazard ratios (HR) and 95% confidence intervals(CI) adjusted for multiple potential confounders. RESULTS Severe daily symptoms (defined assymptoms interfering with daily work or causing nighttime awakenings on a dailybases, reported by 4.3% of participants) were associated with cancer mortality(HR 1.48, 95% CI: 1.04-2.05). This increase was too small to noticeably affectoverall mortality. Mortality was not associated with onset time or frequency ofGERD and was not increased with mild to moderate symptoms. CONCLUSION We have observed an association withGERD and increased cancer mortality in a small group of individuals that hadsevere symptoms. Most patients with mild to moderate GERD can be re-assuredthat their symptoms are not associated with increased mortality.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله فرهاد اسلامی | farhad islami


اکرم پورشمس | akram pourshams


سیاوش ناصری مقدم | siavosh nasseri moghaddam


هومن خادمی | hooman khademi


حسین poutschi | hossein poutschi


مسعود خوش نیا | masoud khoshnia


علیرضا نوروزی | alireza norouzi


تقی امیریانی | taghi amiriani


علی علی عسگری | ali aliasgari


الهام جعفری | elham jafari


شهریار سمنانی | shahryar semnani


کریستین c abnetc | christian c abnetc


پاوول d pharaoh | paul d pharaoh


پاوول brennan | paul brennan


فرین کمانگر | farin kamangar


sanford m dawsey | sanford m dawsey


paolo boffetta | paolo boffetta


رضا ملک زاده | reza malekzadeh


نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/1320
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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