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Middle East Journal of Digestive Diseases، جلد ۶، شماره ۱، صفحات ۱۸-۰
عنوان فارسی
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عنوان انگلیسی Causes of Persistently Elevated Alanine Aminotransferase Levels in Patients who Presented to Two Referral Hospitals in Mashhad, Iran during 2011
چکیده انگلیسی مقاله INTRODUCTION Worldwide, chronic liver disease is a major cause of morbidity and mortality. Causes of elevated serum alanine aminotransferase (ALT) levels vary depending on the population under study. The aim of this study is to evaluate the frequency and causes of persistently elevated ALT levels in patients of the Gastroenterology (GI) Clinics in Ghaem and Emam Reza Hospitals in Mashhad, Iran. METHODS A total of 100 consecutive patients with persistently elevated ALT levels that referred to the GI Clinics at Ghaem and Emam Reza Hospitals in 2011 were studied. Elevated levels were defined as ALT › 40 U/L at least twice within six months. A comprehensive history that included previous surgeries, transfusion, alcohol consumption and medications was obtained. Patients underwent physical examinations, laboratory analyses and ultrasonography studies. When necessary, liver biopsies were performed. RESULTS Patients' mean age was 44.4 ± 11.83 years. Females comprised 62% of cases. Patients presented with the following conditions: non-alcoholic fatty liver disease (NAFLD, 55%), hepatitis B (17%), autoimmune hepatitis (13%), hepatitis C (4%), autoimmune hepatitis and hepatitis C (2%), overlapping autoimmune disease (2%), Wilson disease (1%), celiac disease (1%), alcoholic hepatitis (1%), primary biliary cirrhosis (PBC, 1%), primary sclerosing cholangitis (PSC, 1%), and cryptogenic (2%). CONCLUSION NAFLD was the most common cause of persistently elevated serum ALT levels in this study.
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نویسندگان مقاله احمد خراشاد | ahmad khorashad


حسن وثوقی نیا | hassan vossoughinia


حسن سعادت نیا | hassan saadatnia


عباس اسماعیل زاده | abbas esmaelzadeh


میترا احدی | mitra ahadi


محمد رضا فرزانه فر | mohammad reza farzanehfar


سید موسی الرضا حسینی | seyed mossareza hosseini


منور afzalaghaii | monavvar afzalaghaii


الهام امیرمجدی | elham amirmajdi


لیندا براری | linda barari


فرزاد سعادت نیا | farzad saadatnia


نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/1286
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نوع مقاله منتشر شده Original Article
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