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Middle East Journal of Digestive Diseases، جلد ۵، شماره ۲، صفحات ۹۸-۰
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عنوان انگلیسی Probiotic vs. Placebo in Irritable Bowel Syndrome: A Randomized Controlled Trial
چکیده انگلیسی مقاله BACKGROUND This study assesses the potential effect of Lactobacillus reuteri as a single strain probiotic preparation (Biogaia®) on irritable bowel syndrome (IBS). METHODS Patients diagnosed with IBS who fulfilled Rome III criteria and consented to participate in this study were randomized to receive either the probiotic or an identical placebo once daily for four weeks. Patients used a questionnaire to record any symptoms and adverse reactions over a one-week run-in period and during the final two weeks of intervention. For each group, we calculated the differences between mean scores of the variables and compared the results between groups. RESULTS Frequency of defecation increased in the Biogaia® group and decreased in the placebo group meaningfully. But There were no significant difference in the two groups in other terms of bloating, sense of urgency for defecation, abdominal pain, stool shape, quality of defecation, sense of incomplete evacuation, and treatment satisfaction. CONCLUSION The frequency of defecation increased in the Biogaia® group and decreased in the placebo group, however this study did not classify patients according to diarrhea or constipated subgroups, the efficacy of this drug is not clear. Hence Lactobacillus reuteri was not better than placebo in controlling IBS symptoms in this study. However, considering the significant placebo effect in IBS patients, it may be necessary to conduct studies with larger numbers of participants to better assess the possible beneficial effects of Biogaia.
کلیدواژه‌های انگلیسی مقاله Irritable Bowel Syndrome,Probiotic,Lactobacillus Reuteri
نویسندگان مقاله بهناز amirimani | behnaz amirimani


سپیده نیکفام | sepideh nikfam


مریم الباجی | maryam albaji


سارا واحدی | sara vahedi


سیاوش ناصری مقدم | siavosh nasseri moghaddam


مریم شرفخواه | maryam sharafkhah


رضا انصاری | reza ansari


همایون واحدی | homyoon vahedi


نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/1150
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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