این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Digestive Diseases، جلد ۳، شماره ۲، صفحات ۱۱۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Pegaferon in hepatitis C: Results of a Multicenter Study
چکیده انگلیسی مقاله BACKGROUND Chronic hepatitis C (CHC) is a major contributor to cirrhosis and hepatocellular carcinoma and major global public health problem that causes mortality in both developed and developing countries.For the past decade, treatment with pegylated interferon (peg interferon α) and ribavirin (RBV) has been associated with rates of sustained virologic response of≤ 66% among patients with hepatitis C virus (HCV) infection. In this study, we report the response rate of Iranian treatmentnaΪve CHC patients to Pegaferon, a locally developed pegylated interferon-α±2a (PEG-IFNα2a). METHODS Patients diagnosed with CHC who referred to two university based outpatient clinics in Tehran from December 2007 to May 2011 were enrolled in a single-group, open-labeled experimental design. Eligible patients were above 15 years of age and had HCV infection with evidence of chronic hepatitis. Exclusion criteria included the presence of a debilitating disease, decompensated cirrhosis or refusal to participate in the study. Patients were treated with 180μg Pegaferon weekly in addition to 800-1200 mg daily, weight-based RBV for 24 or 48 weeks depending on genotype. Viral response and adverse effects were recorded. RESULTS A total of 216 patients were enrolled in the study of which 83.3% were male and 16.7% were female. In 93 (43.1%) patients, the HCV RNA viral load was ≥ 800,000 IU/ml before starting treatment. "Astreated analysis" indicated that a total of 168 (77.8%) patients achieved sustained viral response (SVR, undetectable plasma HCV RNA 24 weeks after the last planned dose of study treatment). CONCLUSION This study, with a larger number of participants, confirms the results of a previous study by the authors that Pegaferon, a PEG-IFNα± 2alocally produced in Iran, is effective in treatment-naΪve CHC patients.
کلیدواژه‌های انگلیسی مقاله Hepatitis C virus,Pegylated interferon,Pegaferon,Ribavirin
نویسندگان مقاله حسین جباری | hossein jabari


فرهاد زمانی | farhad zamani


خدیجه حاتمی | khadijeh hatami


ارغوان شیخ الاسلامی | arghavan sheikholeslami


الهام فخارزاده | elham fakharzadeh


کیانا شاهزمانی | kiana shahzamani


هدیه زمانی | hedye zamani


شاهین مرآت | shahin merat


رضا ملک زاده | reza malekzadeh


امیر هوشنگ شریفی | amir houshang sharifi


نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/394
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات