این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Digestive Diseases، جلد ۳، شماره ۲، صفحات ۱۲۶-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Genotypic Analysis of Hepatitis C Virus in Khuzestan Province, Southwestern Iran
چکیده انگلیسی مقاله   Background Hepatitis C virus (HCV) infection is responsible for considerable morbidity and mortality worldwide. The HCV genotype has a geographic distribution and an important role in clinical and histological outcomes. This study determined HCV genotypes and their related risk factors among patients from Khuzestan Province, Southwest Iran. Methods In a cross-sectional study, 223 patients infected with HCV who referred to Ahwaz Jundishapour University Hospitals (AJSUH) and Hepatitis Clinic were enrolled. Specific and nested polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLPs) were performed to determine viral infection and genotype analysis. Liver enzymes including ALT and AST and the correlated risk factors were also determined. Results The HCV genotype distribution was as follows: genotype 1a (41.7%); genotype 1b (2.7%); genotype 2 (4.1%); genotype 3a (31.4%); and genotype 4 (1.8%). There were 42 samples (18.84%) not classified into any of the known HCV subtypes. No patient was infected with more than one genotype. HIV was found in four (1.8%) cases, of which all were intravenous drug users. Univariate analysis demonstrated an in­dependent association of intravenous drug use (IVDU) and genotypes 1a (60.7%) and 3a (30%). Conclusion Our findings suggest that genotypes 1a and 3a are the most com­mon ones among Iranian patients with chronic hepatitis C infection in Khuzestan Province, Southwest, Iran.
کلیدواژه‌های انگلیسی مقاله HCV,Genotyping,Iran
نویسندگان مقاله سید جلال هاشمی | seyed jalal hashemi


عبدالرحیم مسجدی زاده | abolrahim masjedizadeh


علی اکبر شایسته | ali akbar shayesteh


فریبا جلالی | fariba jalali


نشانی اینترنتی http://www.mejdd.org/index.php/mejdd/article/view/397
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات