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Research in Molecular Medicine، جلد ۴، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Long Stress Induced Non-coding Transcripts 5 rs2962586 Polymorphism in Iranian Patients with Bladder Cancer
چکیده انگلیسی مقاله Background: bladder cancer (BC) is the most common genitourinary cancer in Iranians with an unclear etiopathogenesis. Long stress induced non-coding transcript 5 is a member of the 12-member family of long non-coding RNAs, which is abundantly expressed in higher proliferative cells, as well as the cell vulnerable to cellular stress in response to chemical carcinogens. As variations in long non-coding RNAs have been suggested to involve in cancer pathogenesis, this case-control study was performed to determine whether LSINCT5 rs2962586 polymorphism is associated with bladder cancer. Materials and Methods: A group of 150 patients with BC were compared with 143 subjects as a control group. Genotyping of the rs2962586 polymorphism in exon region of the transcript was done using tetra- primer amplification refractory mutation system-polymerase chain reaction (T-ARMS PCR) method. Results: No allelic or genotypic association of the studied polymorphism was observed in this study. However, repeating the analysis in a separate group’s base on smoking resulted in a significant increased risk of BC among smokers. Conclusion: Considering the result of our analyses, it seems that LSINCT5 could not affect individual susceptibility to BC among Iranian patients, however, it can be considered as a disease predictor among smokers.
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نویسندگان مقاله مهلا نظری | mahla nazari
department of biology, islamic azad university, arsanjan branch, arsanjan, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

محبوبه نصیری | mahboobeh nasiri
department of biology, islamic azad university, arsanjan branch, university blvd., arsanjan, fars.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

عباس قادری | abbas ghaderi
sshiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://rmm.mazums.ac.ir/browse.php?a_code=A-10-689-3&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده ژنتیک
نوع مقاله منتشر شده پژوهشی
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