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Research in Molecular Medicine، جلد ۲، شماره ۳، صفحات ۱۷-۲۳
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عنوان انگلیسی Association of FCγRIIA (CD32) polymorphism with susceptibility to brucellosis
چکیده انگلیسی مقاله Background: Brucellosis is the major bacterial zoonoses of global importance caused by Brucella spps. FCγRIIA receptor plays a central role in phagocytosis of IgG2-opsonized bacteria. FCγRIIA exhibits allelic polymorphisms with different capacities for binding IgG2 and phagocytosis. Cells expressing Fc γ RIIa-H131, bind more efficiently to complexes of IgG2 than those expressing the Fc γ RII A -R131 variant. The purpose of this study was to evaluate the association of FCγRIIA polymorphisms with susceptibility to or severity of brucellosis. Materials and Methods: In this study, we evaluated FCγRIIA polymorphisms (R/R131, R/H131, H/H131) in 67 patients with brucellosis and 67 age, sex and geographical matched healthy volunteers. FCγRIIA genotyping was performed by using a sequence-specific primer polymerase chain reaction (SSP-PCR). Results: The comparison of the FCγRIIA genotypes distribution in patients with brucellosis and controls showed a higher frequency in FCγRIIA-R/R131 homozygosity in patients than controls (47.8% vs. 28.4%). Logistic regression analysis showed that there is a significant correlation between R/R131 genotype and brucellosis (OR=2.3, 95%CI=1.3-4.2, P=0.04). Although the frequency of the FCγRIIA-R/R131 was higher in patients with chronic brucellosis compared with acute brucellosis, we did not find any statistically significant differences (53.8% vs. 46.3%, P=0.65). Conclusion: The result of this study showed that the homozygous genotype of FCγRIIA-R/R131 in patients with brucellosis may be associated with susceptibility to brucellosis as a genetic risk factor.
کلیدواژه‌های انگلیسی مقاله Brucellosis, FCγRIIA, Polymorphism
نویسندگان مقاله زهرا حسینی خواه | zahra hosseini khah
molecular and cell biology research center, mazandaran university of medical science, mazandaran, iran

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

زهره بهادری | zohreh bahadori
department of microbiology, faculty of basic sciences, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

علیرضا رفیعی | alireza rafiei
molecular and cell biology research center, mazandaran university of medical science, mazandaran, iran

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

مهرداد حاجیلویی | mehrdad hajilooi
department of immunology, faculty of medicince, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

نشانی اینترنتی http://rmm.mazums.ac.ir/browse.php?a_code=A-10-25-3&slc_lang=en&sid=en
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