این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Research Journal of Pharmacognosy، جلد ۳، شماره ۳، صفحات ۵۵-۶۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Hepatoprotective effect of Acantholimon bracteatum (Girard) Boiss. on formaldehyde-induced liver injury in adult male mice
چکیده انگلیسی مقاله Background and objectives: Acantholimon bracteatum (Girard) Boiss (Plumbaginaceae) is used in variety of diseases including hepatic ailments in the west regions of Iran. In the present study, the hepatoprotective effect of the methanol extract (ME) of A. bracteatum on formaldehyde (FA) induced liver injury has been investigated in adult male mice. Methods: Fifty six adult male mice were divided into 8 groups. The control group received normal saline. Group II (E2) was treated with formaldehyde 10 mg/kg. Group III to VIII (E3-E8) were treated with both FA (10 mg/kg) and the metanol extract at doses of 5, 10, 15, 20, 50 and 100 mg/kg, respectively. All animals were treated for 2 weeks (once every other day). At the end of the morphology, histopathology of liver and serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were evaluated. Results: Formaldehyde induced liver damage both in histology and function. The levels of ALT, AST and ALP enzymes had significantly increased in FA treated group. Administration of ME in all experimental groups significantly reduced serum levels of ALP (p= 0.02); however, AST was reduced significantly just in groups III (E3) and IV(E5) (p
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله e نصیری |
department of anatomical sciences, faculty of medicine, guilan university of medical sciences, rasht, iran. 2student research center, guilan university of medical sciences, rasht, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

s ناصری راد |
student research center, guilan university of medical sciences, rasht, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

a پاسداران لشگری | pasdaran lashgari
department of pharmacognosy, school of pharmacy and research and development center of plants and medicinal chemistry, guilan university of medical sciences, rasht, iran.medicinal plants processing research center, shiraz university of medical sciences, shiraz, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

r گازر |
department of anatomical sciences, faculty of medicine, guilan university of medical sciences, rasht, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

f محمد قاسمی |
department of biochemistry, faculty of medicine, guilan university of medical sciences, rasht, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

z عطرکار روشن | atrkar roushan
department of social medicine, faculty of medicine, guilan university of medical sciences, rasht, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_15638_c0737e11ea7ad352ca4c16e88dbbba9b.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات