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Research Journal of Pharmacognosy، جلد ۳، شماره ۲، صفحات ۹-۱۵
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عنوان انگلیسی Phytochemical constituents, antioxidant activity and toxicity potential of Phlomis olivieri Benth.
چکیده انگلیسی مقاله Background and objectives: Phlomis olivieri Benth. (Lamiaceae) is a medicinal plant widely distributed in Iran. In the present study, we have investigated the phytochemical constituents, antioxidant activity and general toxicity potential of the aerial parts of this species. Methods: Silica gel (normal and reversed phases) and Sephadex LH-20 column chromatographies were used for isolation of compounds from methanol-soluble portion (MSP) of the total extract obtained from P. olivieri aerial parts. The structures of isolated compounds were elucidated using 1H-NMR, 13C-NMR and UV spectral analyses. Antioxidant activity and general toxicity potential of MSP were also evaluated in DPPH free radical-scavenging assay and brine shrimp lethality test (BSLT), respectively. Results: One caffeoylquinic acid derivative, chlorogenic acid (1), one iridoid glycoside, ipolamiide (2), two phenylethanoid glycosides, phlinoside C (3) and verbascoside (5), along with two flavonoids, isoquercetin (4) and naringenin (6) were isolated and identified from MSP. The MSP exhibited considerable antioxidant activity in DPPH method (IC50; 50.4 ± 4.6 µg/mL), compared to BHT (IC50; 18.7 ± 2.1 µg/mL), without any toxic effect in BSLT at the highest tested dose (1000 µg/mL). Conclusion: the results of the present study introduce P. olivieri as a medicinal plant with valuable biological and pharmacological potentials.
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نویسندگان مقاله محمدرضا delnavazi | m r
department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

f محمدی فر |
faculty of pharmacy, international campus, tehran university of medical sciences ic-tums , tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a rustaie |
department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m aghaahmadi |
department of biology, faculty of science, university of isfahan, isfahan, iran
سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

n یاسا |
department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_13769_d859885d12243663a0ee889ad6050653.pdf
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